Genetic and structural characterization of dengue virus involved in the 2023 autochthonous outbreaks in central Italy

Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, there have been many cases of DENV imported from other regions in the past few years, leading to local ou...

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Vydané v:Emerging microbes & infections Ročník 13; číslo 1; s. 2420734
Hlavní autori: Carletti, Fabrizio, Carli, Gabriella De, Spezia, Pietro Giorgio, Gruber, Cesare Ernesto Maria, Prandi, Ingrid Guarnetti, Rueca, Martina, Agresta, Alessandro, Specchiarello, Eliana, Fabeni, Lavinia, Giovanni, Elisa San, Arcuri, Chiara, Spaziante, Martina, Focosi, Daniele, Scognamiglio, Paola, Barca, Alessandra, Nicastri, Emanuele, Girardi, Enrico, Chillemi, Giovanni, Vairo, Francesco, Maggi, Fabrizio
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Taylor & Francis Ltd 01.12.2024
Taylor & Francis
Taylor & Francis Group
Predmet:
arbovirus
Dengue
Dengue fever
genomic surveillance
molecular epidemiology
Viruses
Whole genome sequencing
molecular epidemiology
Dengue
whole-genome sequencing
arbovirus
genomic surveillance
ISSN:2222-1751, 2222-1751
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Shrnutí:Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, there have been many cases of DENV imported from other regions in the past few years, leading to local outbreaks of DENV among people without travel history. Here we describe the epidemiological and molecular investigations of three transmission events locally acquired DENV infections caused by serotypes 1, 2 and 3, respectively, in the Latium Region from August to November 2023. Next-generation or Sanger sequencing was used to obtain the whole genomes, or the complete E-gene of the viruses, respectively. The structure of the DENV-1 and DENV-3 sequences was analysed to identify amino acid changes that were not found in the closest related sequences. The major cluster was supported by DENV-1 (originated in South America), with 42 autochthonous infections almost occurring in the eastern area of Rome, probably due to a single introduction followed by local sustained transmission. Seven DENV-1 subclusters have been identified by mutational and phylogenetic analysis. Structural analysis indicated changes whose meaning can be explained by the adaptation of the virus to human hosts and vectors and their interactions with antibodies and cell receptors.
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Supplemental data for this article can be accessed online at https://doi.org/10.1080/22221751.2024.2420734.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2024.2420734