Amiloride: A review

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics...

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Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system Vol. 21; no. 4; p. 1470320320975893
Main Authors: Sun, Qianhui, Sever, Peter
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01.10.2020
Hindawi Limited
Subjects:
Diuretics
Endocrine system
Hypertension
Liver cirrhosis
Original
Potassium
Sodium
natriuretic
Amiloride
diuretic
hypertension
review
ISSN:1470-3203, 1752-8976, 1752-8976
Online Access:Get full text
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Summary:Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and hepatic cirrhosis with ascites. Historical studies on its use in hypertension were poorly controlled and there is insufficient data on dose-response. It is clearly highly effective in combination with thiazide diuretics where it counteracts the adverse metabolic effects of the thiazides and its use in the Medical Research Council Trial of Older Hypertensive Patients, demonstrated convincing outcome benefits on stroke and coronary events. Recently it has been shown to be as effective as spironolactone in resistant hypertension but there is a real need to establish its potential role in the much larger number of patients with mild to moderate hypertension in whom there is a paucity of information with amiloride particularly across an extended dose range.
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ISSN:1470-3203
1752-8976
1752-8976
DOI:10.1177/1470320320975893