Interspecies transmission of simian foamy virus in a natural predator-prey system

Simian foamy viruses (SFV) are ancient retroviruses of primates and have coevolved with their host species for as many as 30 million years. Although humans are not naturally infected with foamy virus, infection is occasionally acquired through interspecies transmission from nonhuman primates. We sho...

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Bibliographic Details
Published in:Journal of virology Vol. 82; no. 15; p. 7741
Main Authors: Leendertz, Fabian H, Zirkel, Florian, Couacy-Hymann, Emmanuel, Ellerbrok, Heinz, Morozov, Vladimir A, Pauli, Georg, Hedemann, Claudia, Formenty, Pierre, Jensen, Siv Aina, Boesch, Christophe, Junglen, Sandra
Format: Journal Article
Language:English
Published: United States 01.08.2008
Subjects:
Animals
Colobus - virology
Cote d'Ivoire
Female
Male
Molecular Sequence Data
Pan troglodytes - virology
Phylogeny
Retroviridae Infections - transmission
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Simian foamy virus - isolation & purification
Simian foamy virus - physiology
Viral Proteins - genetics
Cote d'Ivoire
ISSN:1098-5514, 1098-5514
Online Access:Get more information
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Summary:Simian foamy viruses (SFV) are ancient retroviruses of primates and have coevolved with their host species for as many as 30 million years. Although humans are not naturally infected with foamy virus, infection is occasionally acquired through interspecies transmission from nonhuman primates. We show that interspecies transmissions occur in a natural hunter-prey system, i.e., between wild chimpanzees and colobus monkeys, both of which harbor their own species-specific strains of SFV. Chimpanzees infected with chimpanzee SFV strains were shown to be coinfected with SFV from colobus monkeys, indicating that apes are susceptible to SFV superinfection, including highly divergent strains from other primate species.
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ISSN:1098-5514
1098-5514
DOI:10.1128/JVI.00549-08