Cost-effectiveness of eHealth-based HIV pre-exposure intervention for recreational drugs using among men who have sex with men in China: a modelling study

Background Recreational drug (RD) is widespread among men who have sex with men (MSM), inspiring "Chemsex" which then exacerbates the spread of HIV. Electronic health (eHealth) can effectively intervene in RD use, while the efficacy of oral pre-exposure prophylaxis (PrEP) in HIV prevention...

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Veröffentlicht in:BMC public health Jg. 25; H. 1; S. 3245 - 14
Hauptverfasser: Jiang, Run, Zhang, Yuyu, Lu, Xinyu, Qin, Gang, Ge, Qiwei, Zhou, Xiaoyi, Ni, Zijun, Xu, Zhongying, Zou, Meiyin, Zhuang, Xun
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 01.10.2025
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Acquired immune deficiency syndrome
Adult
AIDS
Biostatistics
China - epidemiology
Complications and side effects
Cost effectiveness
Cost-Benefit Analysis
Disease prevention
Drug abuse
Dynamic models
E-health
EHealth
Environmental Health
Epidemiology
Health aspects
Health promotion
HIV
HIV infection
HIV Infections - epidemiology
HIV Infections - prevention & control
Homosexuality, Male - statistics & numerical data
Human immunodeficiency virus
Humans
Intervention
Male
Medicine
Medicine & Public Health
Methods
MSM
MSM (Men who have sex with men)
Pre-Exposure Prophylaxis - economics
Pre-Exposure Prophylaxis - methods
PrEP
Prevention
Prophylaxis
Public Health
Recreational Drug
Recreational Drug Use
Risk factors
Sensitivity analysis
Sexually transmitted diseases
Short message service
Social networks
Social organization
STD
Telemedicine - economics
Trends
Vaccine
Young Adult
China
PrEP
HIV
Cost-effectiveness
MSM
EHealth
Recreational Drug
ISSN:1471-2458, 1471-2458
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Zusammenfassung:Background Recreational drug (RD) is widespread among men who have sex with men (MSM), inspiring "Chemsex" which then exacerbates the spread of HIV. Electronic health (eHealth) can effectively intervene in RD use, while the efficacy of oral pre-exposure prophylaxis (PrEP) in HIV prevention has been well-documented. However, eHealth and PrEP have not been implemented on a large-scale in China, and the cost-effectiveness of intervention remains uncertain. This study conducted a dynamic modelling to predict HIV prevalence trends among MSM and the cost-effectiveness of various interventions. Methods Through constructing the HIV-RD model, HIV trends among MSM for the next 30 years are projected. Social network intervention and customized short message service (SMS) in eHealth were combined with PrEP to form 9 intervention scenarios: status quo; social network intervention; SMS; 30%PrEP; 70%PrEP; social network intervention with 30%PrEP; social network intervention with 70%PrEP; SMS with 30%PrEP; SMS with 70%PrEP. The cost-effectiveness of each scenario was evaluated economically, and the results were presented as incremental cost-effectiveness ratio (ICER). Findings. Implementing interventions would prevent 57,937–142,892 HIV infections and 24,091–61,680 deaths. From societal perspective, all interventions' ICERs were from $11,669 to $29,806. Social network intervention was advantageous, saving about $1.97 billion while gaining 169,354 quality-adjusted life years (QALYs). SMS, social network intervention with 30% PrEP were highly cost-effective, with ICERs of $5,869 and $20,325. Sensitivity analysis found that PrEP's costs had the most significant impact. Conclusions In China, implementing eHealth, expanding PrEP, and joint interventions for MSM are cost-effective. Considering funding, social network intervention could be prioritized.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-025-23463-z