Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy
(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aq...
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| Vydáno v: | Pharmaceutics Ročník 13; číslo 4; s. 436 |
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| ISSN: | 1999-4923, 1999-4923 |
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| Abstract | (1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation. |
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| AbstractList | (1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (
= 8, healthy forearm skin) with an Aquaflux
, skin-pH-Meter, Corneometer
and an Epsilon
sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants' skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation. (1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants' skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation.(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants' skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation. (1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation. |
| Author | Klang, Victoria Riethmüller, Christoph Apanovic, Alexandra Litschauer, Brigitte Valenta, Claudia Wolzt, Michael Vater, Claudia |
| AuthorAffiliation | 4 Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria; brigitte.litschauer@meduniwien.ac.at (B.L.); michael.wolzt@meduniwien.ac.at (M.W.) 3 Serend-ip GmbH, Centre for Nanotechnology, 48149 Münster, Germany; info@serend-ip.de 1 Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, 1090 Vienna, Austria; claudia.vater@univie.ac.at (C.V.); a01201528@unet.univie.ac.at (A.A.); claudia.valenta@univie.ac.at (C.V.) 2 Research Platform “Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms”, University of Vienna, 1090 Vienna, Austria |
| AuthorAffiliation_xml | – name: 1 Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, 1090 Vienna, Austria; claudia.vater@univie.ac.at (C.V.); a01201528@unet.univie.ac.at (A.A.); claudia.valenta@univie.ac.at (C.V.) – name: 2 Research Platform “Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms”, University of Vienna, 1090 Vienna, Austria – name: 4 Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria; brigitte.litschauer@meduniwien.ac.at (B.L.); michael.wolzt@meduniwien.ac.at (M.W.) – name: 3 Serend-ip GmbH, Centre for Nanotechnology, 48149 Münster, Germany; info@serend-ip.de |
| Author_xml | – sequence: 1 givenname: Claudia orcidid: 0000-0002-5377-657X surname: Vater fullname: Vater, Claudia – sequence: 2 givenname: Alexandra surname: Apanovic fullname: Apanovic, Alexandra – sequence: 3 givenname: Christoph surname: Riethmüller fullname: Riethmüller, Christoph – sequence: 4 givenname: Brigitte surname: Litschauer fullname: Litschauer, Brigitte – sequence: 5 givenname: Michael surname: Wolzt fullname: Wolzt, Michael – sequence: 6 givenname: Claudia surname: Valenta fullname: Valenta, Claudia – sequence: 7 givenname: Victoria orcidid: 0000-0003-2561-4378 surname: Klang fullname: Klang, Victoria |
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| Keywords | surfactants transepidermal water loss corneocytes lecithins dermal texture index skin hydration sodium dodecyl sulfate phospholipids atomic force microscopy natural moisturizing factor |
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| SubjectTerms | atomic force microscopy corneocytes Fatty acids Hydration lecithins Lipids Microscopy Morphology Pharmaceuticals phospholipids Physiology Skin Skin diseases Sodium sodium dodecyl sulfate Soybeans Surfactants |
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| Title | Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy |
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