Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy

(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aq...

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Published in:Pharmaceutics Vol. 13; no. 4; p. 436
Main Authors: Vater, Claudia, Apanovic, Alexandra, Riethmüller, Christoph, Litschauer, Brigitte, Wolzt, Michael, Valenta, Claudia, Klang, Victoria
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 24.03.2021
MDPI
Subjects:
atomic force microscopy
corneocytes
Fatty acids
Hydration
lecithins
Lipids
Microscopy
Morphology
Pharmaceuticals
phospholipids
Physiology
Skin
Skin diseases
Sodium
sodium dodecyl sulfate
Soybeans
Surfactants
United Kingdom > UK
Germany
surfactants
transepidermal water loss
corneocytes
lecithins
dermal texture index
skin hydration
sodium dodecyl sulfate
phospholipids
atomic force microscopy
natural moisturizing factor
ISSN:1999-4923, 1999-4923
Online Access:Get full text
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Summary:(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13040436