Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development...

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Vydáno v:Bioengineering (Basel) Ročník 7; číslo 3; s. 112
Hlavní autoři: Allwardt, Vanessa, Ainscough, Alexander J., Viswanathan, Priyalakshmi, Sherrod, Stacy D., McLean, John A., Haddrick, Malcolm, Pensabene, Virginia
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 16.09.2020
MDPI
Témata:
Bioengineering
Biology
Cell culture
Clinical trials
Commercialization
Cytotoxicity
Employees
Female reproductive system
gap analysis
Likert scale
Nonprofit organizations
organ-on-a-chip
Organs
Pharmaceutical industry
Polls & surveys
Product development
quality management
Quality standards
Review
Skin
Sports injuries
Technology assessment
technology-led strategy
Translation
validation
United Kingdom > UK
United States > US
quality management
microphysiological systems
organotypic culture models
gap analysis
translation
technology-led strategy
body-on-a-chip
organ-on-a-chip
validation
ISSN:2306-5354, 2306-5354
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Abstract Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.
AbstractList Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.
Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.
Author McLean, John A.
Viswanathan, Priyalakshmi
Allwardt, Vanessa
Haddrick, Malcolm
Pensabene, Virginia
Ainscough, Alexander J.
Sherrod, Stacy D.
AuthorAffiliation 3 Medicines Discovery Catapult, Alderley Park, Alderley Edge, Macclesfield SK10 4TG, UK; priya.viswanathan@md.catapult.org.uk (P.V.); malcolm.haddrick@md.catapult.org.uk (M.H.)
5 School of Electronic and Electrical Engineering, School of Medicine, Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds LS2 9JT, UK
1 Center for Innovative Technology, Department of Chemistry, Vanderbilt University, Nashville, TN 37212, USA; vanessa.allwardt@Vanderbilt.Edu (V.A.); stacy.d.sherrod@vanderbilt.edu (S.D.S.); john.a.mclean@Vanderbilt.Edu (J.A.M.)
2 National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK; alex.ainscough14@imperial.ac.uk
4 Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA
AuthorAffiliation_xml – name: 1 Center for Innovative Technology, Department of Chemistry, Vanderbilt University, Nashville, TN 37212, USA; vanessa.allwardt@Vanderbilt.Edu (V.A.); stacy.d.sherrod@vanderbilt.edu (S.D.S.); john.a.mclean@Vanderbilt.Edu (J.A.M.)
– name: 5 School of Electronic and Electrical Engineering, School of Medicine, Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds LS2 9JT, UK
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Cites_doi 10.1039/C7LC00512A
10.1080/03602532.2019.1632889
10.1038/s41586-019-1291-3
10.1038/s41598-017-06361-2
10.1038/s41551-019-0497-x
10.1038/s41551-019-0495-z
10.1038/s41598-019-48347-2
10.1016/j.addr.2018.06.007
10.1021/acssensors.8b01549
10.3389/fmicb.2018.01835
10.1021/acs.iecr.8b05693
10.1152/physrev.00018.2018
10.1111/bcp.13793
10.1039/C6LC00259E
10.1038/s41598-018-32523-x
10.1038/nm.3545
10.1124/dmd.116.071456
10.1038/s41573-019-0048-x
10.1016/j.biomaterials.2018.08.006
10.1002/elps.201500031
10.1186/s13059-017-1215-1
10.3389/fbioe.2019.00251
10.1016/j.stemcr.2018.08.013
10.1021/acs.jproteome.6b01004
10.1177/0018726708094863
10.1039/c3lc50243k
10.1126/scitranslmed.3004249
10.1039/C6LC01554A
10.1016/j.apsb.2016.07.012
10.1371/journal.pone.0158674
10.1038/srep20270
10.1038/nmeth.3697
10.1039/C7LC00942A
10.1021/acs.chemrestox.9b00333
10.1016/j.jbiosc.2018.10.019
10.1038/s41467-020-15058-6
10.1177/1535370217708976
10.3389/fbioe.2019.00013
10.1039/C9LC00338J
10.1038/nrgastro.2017.110
10.1038/s41598-018-22749-0
10.1038/nbt.2989
10.1124/pr.118.015768
10.1007/s40495-019-00200-w
10.1038/s41598-017-08879-x
10.1016/j.tibtech.2019.06.006
10.1038/nbt.4226
10.1146/annurev-biochem-061516-044952
10.1038/nrmicro.2016.17
10.1016/j.trsl.2016.08.002
10.1039/b612140c
10.1038/nature25979
10.1016/j.ymeth.2018.04.029
10.1038/s41569-018-0108-7
10.1016/j.copbio.2018.03.011
10.1146/annurev-pharmtox-010919-023309
10.1038/srep37471
10.1126/science.1260419
10.1038/s41598-019-45656-4
10.1016/j.snb.2019.05.030
10.1038/s41598-017-13601-y
10.1039/c3lc50234a
10.1146/annurev-pharmtox-010919-023628
10.1038/srep20030
10.1039/c3lc50558h
10.1038/s41551-019-0397-0
10.1063/1.4984768
10.1038/nrd4539
10.1038/s41551-019-0498-9
10.1371/journal.pone.0117685
10.1039/C5LC00633C
10.1016/j.stem.2018.02.011
10.1038/srep42113
10.1039/c3lc50227a
10.1186/s12974-016-0760-y
10.1038/s41551-017-0069
10.1007/s43032-020-00184-9
10.1039/C8LC00746B
10.1002/cpt.742
10.1016/j.bpj.2019.11.3352
10.1016/j.pharmthera.2015.11.012
10.1016/j.biomaterials.2018.07.062
10.1126/scitranslmed.aax5516
10.1016/j.stemcr.2018.03.012
10.1021/acs.jproteome.8b00302
10.1371/journal.pone.0180167
10.1038/nrd.2016.245
10.1016/j.biomaterials.2016.11.012
10.1021/acs.analchem.0c00651
10.1039/C9LC00211A
10.3390/bioengineering6040103
10.1146/annurev-bioeng-060418-052305
10.1016/j.tibtech.2017.08.003
10.1016/j.bcp.2013.06.029
10.1021/acs.analchem.9b02224
10.1371/journal.ppat.1006480
10.1136/gutjnl-2013-306423
10.3390/ijms20246178
10.1007/s10439-017-1797-5
10.1126/scitranslmed.aav1386
10.1002/smll.201905055
10.1126/science.1188302
10.1038/ncomms14584
10.1373/clinchem.2015.238261
10.1016/j.ejps.2016.10.020
10.3389/fbioe.2020.00647
10.1002/mas.21553
10.1039/C4LC00999A
10.1016/j.semcdb.2018.05.001
10.1039/C5LC00611B
10.1039/C9LC00285E
10.1063/1.4934713
10.1016/j.phanu.2018.02.001
10.1021/acs.chemrestox.6b00401
10.1016/j.molmed.2019.07.006
10.1039/C8LC00285A
10.1038/srep42296
10.1021/bp034077d
10.1016/j.trac.2019.04.006
10.1016/j.microc.2017.04.018
10.1016/j.addr.2018.06.001
10.1038/srep14554
10.1146/annurev-pharmtox-010716-104748
10.1016/j.jcmgh.2017.12.001
10.1038/s41575-018-0028-3
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2020 by the authors. 2020
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Issue 3
Keywords quality management
microphysiological systems
organotypic culture models
gap analysis
translation
technology-led strategy
body-on-a-chip
organ-on-a-chip
validation
Language English
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References ref_137
Norris (ref_84) 2017; 16
ref_139
ref_138
Gnecco (ref_2) 2017; 45
Buchner (ref_129) 2019; 58
Cochrane (ref_73) 2019; 140
Herland (ref_19) 2020; 4
ref_99
Vogt (ref_117) 2017; 7
ref_130
Luan (ref_116) 2019; 38
ref_133
Varma (ref_55) 2018; 18
ref_135
Stucki (ref_25) 2018; 8
ref_134
Brown (ref_1) 2015; 9
Skardal (ref_94) 2017; 7
Pamies (ref_68) 2018; 35
Wolf (ref_115) 2017; 7
Gutierrez (ref_86) 2018; 17
ref_15
Gao (ref_106) 2017; 30
Sin (ref_31) 2004; 20
Huh (ref_23) 2012; 4
Hirama (ref_61) 2019; 127
Weaver (ref_131) 2020; 19
Magliaro (ref_44) 2019; 7
Chen (ref_100) 2019; 51
Fagerberg (ref_87) 2015; 347
Halaidych (ref_45) 2018; 10
Lu (ref_52) 2017; 86
Ahluwalia (ref_41) 2017; 7
ref_21
Visnovitz (ref_98) 2019; 51
Li (ref_29) 2017; 11
Spanogiannopoulos (ref_120) 2016; 14
Spanogiannopoulos (ref_103) 2018; 15
Shang (ref_79) 2019; 295
Shin (ref_126) 2019; 7
Lamichhane (ref_107) 2018; 149
Geremia (ref_136) 2018; 136
Zhang (ref_78) 2017; 114
Esch (ref_18) 2015; 14
Rowland (ref_40) 2019; 85
Wilson (ref_39) 2017; 179
Chou (ref_132) 2020; 4
Osaki (ref_70) 2018; 52
Brown (ref_91) 2016; 13
Baruch (ref_6) 2008; 61
Fiocchi (ref_113) 2017; 14
Gazzaniga (ref_124) 2019; 3
Domansky (ref_62) 2013; 13
Kieninger (ref_80) 2018; 18
ref_140
ref_89
ref_141
Xiao (ref_12) 2017; 8
Jain (ref_24) 2018; 103
Li (ref_88) 2020; 99
Vernetti (ref_83) 2017; 7
Kho (ref_108) 2018; 9
Volpato (ref_47) 2018; 11
Huh (ref_128) 2010; 328
Wang (ref_93) 2019; 91
Wnorowski (ref_67) 2019; 140
Ongaro (ref_64) 2020; 92
McAleer (ref_90) 2019; 9
Dempsey (ref_122) 2019; 5
Hughes (ref_35) 2017; 242
Park (ref_43) 2020; 38
Agrawal (ref_16) 2017; 17
Raimondi (ref_123) 2019; 25
Wufuer (ref_11) 2016; 6
Ulvestad (ref_49) 2013; 86
McAleer (ref_32) 2019; 11
Dolega (ref_66) 2017; 35
Tang (ref_111) 2019; 16
Zhang (ref_7) 2017; 17
Wagner (ref_30) 2013; 13
Sherrod (ref_56) 2016; 62
Nguyen (ref_63) 2019; 19
Jang (ref_27) 2019; 11
Xia (ref_46) 2016; 6
Long (ref_26) 2016; 44
Pereiro (ref_65) 2019; 19
Yang (ref_76) 2020; 8
Wikswo (ref_42) 2013; 13
Musah (ref_57) 2017; 1
Chen (ref_74) 2020; 118
Abaci (ref_10) 2015; 15
Oleaga (ref_92) 2018; 182
Magliaro (ref_50) 2019; 9
Benam (ref_58) 2016; 13
Tan (ref_72) 2020; 16
(ref_9) 2018; 22
Clarke (ref_110) 2020; 60
Richardson (ref_13) 2019; 27
Gil (ref_53) 2015; 36
Young (ref_82) 2019; 4
Ghaisas (ref_105) 2016; 158
Lee (ref_8) 2018; 18
Lee (ref_22) 2015; 15
ref_114
Luttge (ref_5) 2018; 6
Wagner (ref_28) 2013; 13
Shemesh (ref_54) 2015; 15
ref_118
Ehrlich (ref_20) 2019; 21
Blutt (ref_125) 2018; 5
Cryan (ref_109) 2019; 99
Edington (ref_38) 2018; 8
Korte (ref_51) 2020; 60
Nuzzo (ref_96) 2020; 33
Partyka (ref_75) 2017; 115
Maier (ref_104) 2018; 555
Novak (ref_34) 2018; 58
Bhatia (ref_60) 2014; 32
Santbergen (ref_81) 2019; 115
Hasin (ref_85) 2017; 18
Novak (ref_33) 2020; 4
Miri (ref_71) 2019; 198
Royo (ref_97) 2017; 98
Zimmermann (ref_95) 2019; 570
Boon (ref_48) 2020; 11
Martorell (ref_77) 2016; 37
Machiels (ref_112) 2015; 64
Oleaga (ref_36) 2016; 6
Toepke (ref_59) 2006; 6
Blundell (ref_14) 2016; 16
Wang (ref_127) 2014; 20
Shi (ref_69) 2017; 16
ref_102
Clarke (ref_119) 2019; 71
ref_3
Maoz (ref_37) 2018; 36
ref_4
Ortega (ref_17) 2019; 19
Xie (ref_101) 2016; 6
Lehouritis (ref_121) 2015; 5
References_xml – volume: 17
  start-page: 3447
  year: 2017
  ident: ref_16
  article-title: Skeletal muscle-on-a-chip: An in vitro model to evaluate tissue formation and injury
  publication-title: Lab Chip
  doi: 10.1039/C7LC00512A
– volume: 51
  start-page: 178
  year: 2019
  ident: ref_100
  article-title: A comprehensive review of cytochrome p450 2e1 for xenobiotic metabolism
  publication-title: Drug Metab. Rev.
  doi: 10.1080/03602532.2019.1632889
– volume: 570
  start-page: 462
  year: 2019
  ident: ref_95
  article-title: Mapping human microbiome drug metabolism by gut bacteria and their genes
  publication-title: Nature
  doi: 10.1038/s41586-019-1291-3
– volume: 7
  start-page: 5867
  year: 2017
  ident: ref_115
  article-title: The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-06361-2
– volume: 4
  start-page: 407
  year: 2020
  ident: ref_33
  article-title: Robotic fluidic coupling and interrogation of multiple vascularized organ chips
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0497-x
– volume: 4
  start-page: 394
  year: 2020
  ident: ref_132
  article-title: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0495-z
– volume: 9
  start-page: 11890
  year: 2019
  ident: ref_50
  article-title: Allometric scaling of physiologically-relevant organoids
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-48347-2
– volume: 140
  start-page: 68
  year: 2019
  ident: ref_73
  article-title: Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.06.007
– volume: 4
  start-page: 1454
  year: 2019
  ident: ref_82
  article-title: Monitoring of microphysiological systems: Integrating sensors and real-time data analysis toward autonomous decision-making
  publication-title: ACS Sens.
  doi: 10.1021/acssensors.8b01549
– volume: 9
  start-page: 1835
  year: 2018
  ident: ref_108
  article-title: The human gut microbiome–A potential controller of wellness and disease
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.01835
– volume: 58
  start-page: 6957
  year: 2019
  ident: ref_129
  article-title: Specifying technology readiness levels for the chemical industry
  publication-title: Ind. Eng. Chem. Res.
  doi: 10.1021/acs.iecr.8b05693
– volume: 99
  start-page: 1877
  year: 2019
  ident: ref_109
  article-title: The microbiota-gut-brain axis
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00018.2018
– volume: 85
  start-page: 216
  year: 2019
  ident: ref_40
  article-title: Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: A novel approach to characterize variability in drug exposure
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/bcp.13793
– volume: 16
  start-page: 3065
  year: 2016
  ident: ref_14
  article-title: A microphysiological model of the human placental barrier
  publication-title: Lab Chip
  doi: 10.1039/C6LC00259E
– volume: 8
  start-page: 14359
  year: 2018
  ident: ref_25
  article-title: Medium throughput breathing human primary cell alveolus-on-chip model
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-32523-x
– volume: 20
  start-page: 616
  year: 2014
  ident: ref_127
  article-title: Modeling the mitochondrial cardiomyopathy of barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
  publication-title: Nat. Med.
  doi: 10.1038/nm.3545
– ident: ref_141
– volume: 44
  start-page: 1940
  year: 2016
  ident: ref_26
  article-title: Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.116.071456
– ident: ref_4
– volume: 19
  start-page: 131
  year: 2020
  ident: ref_131
  article-title: Managing the challenge of drug-induced liver injury: A roadmap for the development and deployment of preclinical predictive models
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0048-x
– volume: 198
  start-page: 204
  year: 2019
  ident: ref_71
  article-title: Multiscale bioprinting of vascularized models
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.08.006
– volume: 36
  start-page: 2156
  year: 2015
  ident: ref_53
  article-title: Stability of energy metabolites—An often overlooked issue in metabolomics studies: A review
  publication-title: Electrophoresis
  doi: 10.1002/elps.201500031
– ident: ref_135
– volume: 18
  start-page: 83
  year: 2017
  ident: ref_85
  article-title: Multi-omics approaches to disease
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1215-1
– volume: 7
  start-page: 251
  year: 2019
  ident: ref_44
  article-title: Oxygen consumption characteristics in 3d constructs depend on cell density
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2019.00251
– volume: 11
  start-page: 897
  year: 2018
  ident: ref_47
  article-title: Reproducibility of molecular phenotypes after long-term differentiation to human ipsc-derived neurons: A multi-site omics study
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2018.08.013
– volume: 16
  start-page: 1364
  year: 2017
  ident: ref_84
  article-title: Integrated, high-throughput, multiomics platform enables data-driven construction of cellular responses and reveals global drug mechanisms of action
  publication-title: J. Proteome Res.
  doi: 10.1021/acs.jproteome.6b01004
– volume: 61
  start-page: 1139
  year: 2008
  ident: ref_6
  article-title: Survey response rate levels and trends in organizational research
  publication-title: Hum. Relat.
  doi: 10.1177/0018726708094863
– volume: 13
  start-page: 3496
  year: 2013
  ident: ref_42
  article-title: Scaling and systems biology for integrating multiple organs-on-a-chip
  publication-title: Lab Chip
  doi: 10.1039/c3lc50243k
– volume: 4
  start-page: ra147
  year: 2012
  ident: ref_23
  article-title: A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3004249
– volume: 17
  start-page: 2395
  year: 2017
  ident: ref_7
  article-title: Organ-on-a-chip devices advance to market
  publication-title: Lab Chip
  doi: 10.1039/C6LC01554A
– volume: 6
  start-page: 374
  year: 2016
  ident: ref_101
  article-title: An update on the role of intestinal cytochrome p450 enzymes in drug disposition
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2016.07.012
– ident: ref_21
  doi: 10.1371/journal.pone.0158674
– volume: 6
  start-page: 20270
  year: 2016
  ident: ref_46
  article-title: Transcriptional comparison of human induced and primary midbrain dopaminergic neurons
  publication-title: Sci. Rep.
  doi: 10.1038/srep20270
– volume: 13
  start-page: 151
  year: 2016
  ident: ref_58
  article-title: Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3697
– volume: 18
  start-page: 1274
  year: 2018
  ident: ref_80
  article-title: Microsensor systems for cell metabolism–From 2d culture to organ-on-chip
  publication-title: Lab Chip
  doi: 10.1039/C7LC00942A
– volume: 33
  start-page: 119
  year: 2020
  ident: ref_96
  article-title: The microbiome factor in drug discovery and development
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/acs.chemrestox.9b00333
– volume: 127
  start-page: 641
  year: 2019
  ident: ref_61
  article-title: Glass-based organ-on-a-chip device for restricting small molecular absorption
  publication-title: J. Biosci. Bioeng.
  doi: 10.1016/j.jbiosc.2018.10.019
– ident: ref_3
– volume: 11
  start-page: 1393
  year: 2020
  ident: ref_48
  article-title: Amino acid levels determine metabolism and cyp450 function of hepatocytes and hepatoma cell lines
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-15058-6
– ident: ref_140
– volume: 242
  start-page: 1593
  year: 2017
  ident: ref_35
  article-title: Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems
  publication-title: Exp. Biol. Med.
  doi: 10.1177/1535370217708976
– volume: 7
  start-page: 13
  year: 2019
  ident: ref_126
  article-title: A robust longitudinal co-culture of obligate anaerobic gut microbiome with human intestinal epithelium in an anoxic-oxic interface-on-a-chip
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2019.00013
– volume: 19
  start-page: 3706
  year: 2019
  ident: ref_63
  article-title: Robust chemical bonding of pmma microfluidic devices to porous pete membranes for reliable cytotoxicity testing of drugs
  publication-title: Lab Chip
  doi: 10.1039/C9LC00338J
– volume: 14
  start-page: 739
  year: 2017
  ident: ref_113
  article-title: The ibd interactome: An integrated view of aetiology, pathogenesis and therapy
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2017.110
– ident: ref_134
– volume: 8
  start-page: 4530
  year: 2018
  ident: ref_38
  article-title: Interconnected microphysiological systems for quantitative biology and pharmacology studies
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-22749-0
– volume: 32
  start-page: 760
  year: 2014
  ident: ref_60
  article-title: Microfluidic organs-on-chips
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2989
– volume: 71
  start-page: 198
  year: 2019
  ident: ref_119
  article-title: Gut reactions: Breaking down xenobiotic–microbiome interactions
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.118.015768
– volume: 5
  start-page: 481
  year: 2019
  ident: ref_122
  article-title: Microbiome is a functional modifier of p450 drug metabolism
  publication-title: Curr. Pharmacol. Rep.
  doi: 10.1007/s40495-019-00200-w
– volume: 7
  start-page: 8837
  year: 2017
  ident: ref_94
  article-title: Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-08879-x
– volume: 38
  start-page: 99
  year: 2020
  ident: ref_43
  article-title: Integrating organs-on-chips: Multiplexing, scaling, vascularization, and innervation
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2019.06.006
– volume: 36
  start-page: 865
  year: 2018
  ident: ref_37
  article-title: A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4226
– volume: 86
  start-page: 277
  year: 2017
  ident: ref_52
  article-title: Metabolite measurement: Pitfalls to avoid and practices to follow
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev-biochem-061516-044952
– volume: 51
  start-page: 1
  year: 2019
  ident: ref_98
  article-title: Systems biology approaches to investigating the roles of extracellular vesicles in human diseases
  publication-title: Exp. Mol. Med.
– volume: 14
  start-page: 273
  year: 2016
  ident: ref_120
  article-title: The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2016.17
– volume: 179
  start-page: 204
  year: 2017
  ident: ref_39
  article-title: Gut microbiome interactions with drug metabolism, efficacy, and toxicity
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2016.08.002
– volume: 6
  start-page: 1484
  year: 2006
  ident: ref_59
  article-title: Pdms absorption of small molecules and consequences in microfluidic applications
  publication-title: Lab Chip
  doi: 10.1039/b612140c
– volume: 555
  start-page: 623
  year: 2018
  ident: ref_104
  article-title: Extensive impact of non-antibiotic drugs on human gut bacteria
  publication-title: Nature
  doi: 10.1038/nature25979
– volume: 149
  start-page: 3
  year: 2018
  ident: ref_107
  article-title: Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe
  publication-title: Methods
  doi: 10.1016/j.ymeth.2018.04.029
– volume: 16
  start-page: 137
  year: 2019
  ident: ref_111
  article-title: Dietary metabolism, the gut microbiome, and heart failure
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-018-0108-7
– volume: 52
  start-page: 116
  year: 2018
  ident: ref_70
  article-title: Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2018.03.011
– volume: 60
  start-page: 529
  year: 2020
  ident: ref_51
  article-title: Unlocking personalized biomedicine and drug discovery with human induced pluripotent stem cell–derived cardiomyocytes: Fit for purpose or forever elusive?
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-010919-023309
– volume: 6
  start-page: 37471
  year: 2016
  ident: ref_11
  article-title: Skin-on-a-chip model simulating inflammation, edema and drug-based treatment
  publication-title: Sci. Rep.
  doi: 10.1038/srep37471
– volume: 347
  start-page: 1260419
  year: 2015
  ident: ref_87
  article-title: Tissue-based map of the human proteome
  publication-title: Science
  doi: 10.1126/science.1260419
– volume: 9
  start-page: 9619
  year: 2019
  ident: ref_90
  article-title: On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-45656-4
– volume: 295
  start-page: 30
  year: 2019
  ident: ref_79
  article-title: Chip modularity enables molecular information access from organ-on-chip devices with quality control
  publication-title: Sens. Actuators B Chem.
  doi: 10.1016/j.snb.2019.05.030
– volume: 7
  start-page: 13537
  year: 2017
  ident: ref_117
  article-title: Gut microbiome alterations in alzheimer’s disease
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-13601-y
– ident: ref_137
– volume: 13
  start-page: 3538
  year: 2013
  ident: ref_28
  article-title: A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3d human liver and skin tissue co-culture
  publication-title: Lab Chip
  doi: 10.1039/c3lc50234a
– volume: 60
  start-page: 477
  year: 2020
  ident: ref_110
  article-title: Microbiota-gut-brain axis: New therapeutic opportunities
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-010919-023628
– volume: 6
  start-page: 20030
  year: 2016
  ident: ref_36
  article-title: Multi-organ toxicity demonstration in a functional human in vitro system composed of four organs
  publication-title: Sci. Rep.
  doi: 10.1038/srep20030
– volume: 13
  start-page: 3956
  year: 2013
  ident: ref_62
  article-title: Clear castable polyurethane elastomer for fabrication of microfluidic devices
  publication-title: Lab Chip
  doi: 10.1039/c3lc50558h
– volume: 3
  start-page: 520
  year: 2019
  ident: ref_124
  article-title: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0397-0
– volume: 11
  start-page: 034114
  year: 2017
  ident: ref_29
  article-title: Drug absorption related nephrotoxicity assessment on an intestine-kidney chip
  publication-title: Biomicrofluidics
  doi: 10.1063/1.4984768
– volume: 14
  start-page: 248
  year: 2015
  ident: ref_18
  article-title: Organs-on-chips at the frontiers of drug discovery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4539
– volume: 4
  start-page: 421
  year: 2020
  ident: ref_19
  article-title: Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0498-9
– ident: ref_89
  doi: 10.1371/journal.pone.0117685
– volume: 15
  start-page: 4114
  year: 2015
  ident: ref_54
  article-title: Flow-induced stress on adherent cells in microfluidic devices
  publication-title: Lab Chip
  doi: 10.1039/C5LC00633C
– volume: 22
  start-page: 310
  year: 2018
  ident: ref_9
  article-title: Organs-on-a-chip: A fast track for engineered human tissues in drug development
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.02.011
– volume: 7
  start-page: 42113
  year: 2017
  ident: ref_41
  article-title: Allometric scaling in-vitro
  publication-title: Sci. Rep.
  doi: 10.1038/srep42113
– volume: 13
  start-page: 3555
  year: 2013
  ident: ref_30
  article-title: Skin and hair on-a-chip: In vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
  publication-title: Lab Chip
  doi: 10.1039/c3lc50227a
– volume: 13
  start-page: 306
  year: 2016
  ident: ref_91
  article-title: Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-016-0760-y
– volume: 1
  start-page: 0069
  year: 2017
  ident: ref_57
  article-title: Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-017-0069
– volume: 27
  start-page: 1562
  year: 2019
  ident: ref_13
  article-title: Fetal membrane organ-on-chip: An innovative approach to study cellular interactions
  publication-title: Reprod. Sci.
  doi: 10.1007/s43032-020-00184-9
– volume: 18
  start-page: 3333
  year: 2018
  ident: ref_55
  article-title: Caring for cells in microsystems: Principles and practices of cell-safe device design and operation
  publication-title: Lab Chip
  doi: 10.1039/C8LC00746B
– volume: 35
  start-page: 353
  year: 2018
  ident: ref_68
  article-title: Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
  publication-title: ALTEX Altern. Anim. Exp.
– volume: 103
  start-page: 332
  year: 2018
  ident: ref_24
  article-title: Primary human lung alveolus-on-a-chip model of intravascular thrombosis for assessment of therapeutics
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1002/cpt.742
– volume: 118
  start-page: 621a
  year: 2020
  ident: ref_74
  article-title: A microphysiologic body-in-a-cube system with near-physiologic amounts of blood surrogate
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2019.11.3352
– volume: 114
  start-page: E2293
  year: 2017
  ident: ref_78
  article-title: Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 158
  start-page: 52
  year: 2016
  ident: ref_105
  article-title: Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2015.11.012
– ident: ref_139
– volume: 182
  start-page: 176
  year: 2018
  ident: ref_92
  article-title: Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.07.062
– volume: 11
  start-page: eaax5516
  year: 2019
  ident: ref_27
  article-title: Reproducing human and cross-species drug toxicities using a liver-chip
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aax5516
– volume: 37
  start-page: 2614
  year: 2016
  ident: ref_77
  article-title: Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 10
  start-page: 1642
  year: 2018
  ident: ref_45
  article-title: Inflammatory responses and barrier function of endothelial cells derived from human induced pluripotent stem cells
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2018.03.012
– volume: 17
  start-page: 3396
  year: 2018
  ident: ref_86
  article-title: An integrated, high-throughput strategy for multiomic systems level analysis
  publication-title: J. Proteome Res.
  doi: 10.1021/acs.jproteome.8b00302
– ident: ref_118
  doi: 10.1371/journal.pone.0180167
– volume: 16
  start-page: 115
  year: 2017
  ident: ref_69
  article-title: Induced pluripotent stem cell technology: A decade of progress
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.245
– volume: 115
  start-page: 30
  year: 2017
  ident: ref_75
  article-title: Mechanical stress regulates transport in a compliant 3d model of the blood-brain barrier
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.11.012
– volume: 92
  start-page: 6693
  year: 2020
  ident: ref_64
  article-title: Polylactic is a sustainable, low absorption, low autofluorescence alternative to other plastics for microfluidic and organ-on-chip applications
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.0c00651
– volume: 19
  start-page: 2296
  year: 2019
  ident: ref_65
  article-title: Nip the bubble in the bud: A guide to avoid gas nucleation in microfluidics
  publication-title: Lab Chip
  doi: 10.1039/C9LC00211A
– ident: ref_15
  doi: 10.3390/bioengineering6040103
– volume: 21
  start-page: 219
  year: 2019
  ident: ref_20
  article-title: Challenges and opportunities in the design of liver-on-chip microdevices
  publication-title: Annu. Rev. Biomed. Eng.
  doi: 10.1146/annurev-bioeng-060418-052305
– volume: 35
  start-page: 1035
  year: 2017
  ident: ref_66
  article-title: Deciphering cell intrinsic properties: A key issue for robust organoid production
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2017.08.003
– volume: 86
  start-page: 691
  year: 2013
  ident: ref_49
  article-title: Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2013.06.029
– volume: 91
  start-page: 8667
  year: 2019
  ident: ref_93
  article-title: Analysis of an integrated human multiorgan microphysiological system for combined tolcapone metabolism and brain metabolomics
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.9b02224
– ident: ref_114
  doi: 10.1371/journal.ppat.1006480
– volume: 64
  start-page: 447
  year: 2015
  ident: ref_112
  article-title: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in ibd
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-306423
– ident: ref_102
  doi: 10.3390/ijms20246178
– volume: 45
  start-page: 1758
  year: 2017
  ident: ref_2
  article-title: Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium
  publication-title: Ann. Biomed. Eng.
  doi: 10.1007/s10439-017-1797-5
– volume: 11
  start-page: eaav1386
  year: 2019
  ident: ref_32
  article-title: Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aav1386
– volume: 16
  start-page: 1905055
  year: 2020
  ident: ref_72
  article-title: Recreating physiological environments in vitro: Design rules for microfluidic-based vascularized tissue constructs
  publication-title: Small
  doi: 10.1002/smll.201905055
– volume: 328
  start-page: 1662
  year: 2010
  ident: ref_128
  article-title: Reconstituting organ-level lung functions on a chip
  publication-title: Science
  doi: 10.1126/science.1188302
– ident: ref_138
– volume: 8
  start-page: 14584
  year: 2017
  ident: ref_12
  article-title: A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14584
– volume: 62
  start-page: 77
  year: 2016
  ident: ref_56
  article-title: Systems-wide high-dimensional data acquisition and informatics using structural mass spectrometry strategies
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2015.238261
– volume: 98
  start-page: 51
  year: 2017
  ident: ref_97
  article-title: Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2016.10.020
– volume: 8
  start-page: 647
  year: 2020
  ident: ref_76
  article-title: Laminar flow protects vascular endothelial tight junctions and barrier function via maintaining the expression of long non-coding rna malat1
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2020.00647
– volume: 38
  start-page: 22
  year: 2019
  ident: ref_116
  article-title: Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders
  publication-title: Mass Spectrom. Rev.
  doi: 10.1002/mas.21553
– volume: 15
  start-page: 882
  year: 2015
  ident: ref_10
  article-title: Pumpless microfluidic platform for drug testing on human skin equivalents
  publication-title: Lab Chip
  doi: 10.1039/C4LC00999A
– volume: 99
  start-page: 3
  year: 2020
  ident: ref_88
  article-title: Pathway perturbations in signaling networks: Linking genotype to phenotype
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2018.05.001
– volume: 15
  start-page: 3822
  year: 2015
  ident: ref_22
  article-title: 3d liver models on a microplatform: Well-defined culture, engineering of liver tissue and liver-on-a-chip
  publication-title: Lab Chip
  doi: 10.1039/C5LC00611B
– ident: ref_130
– volume: 19
  start-page: 2568
  year: 2019
  ident: ref_17
  article-title: Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted il-6 and tnf-α
  publication-title: Lab Chip
  doi: 10.1039/C9LC00285E
– volume: 9
  start-page: 054124
  year: 2015
  ident: ref_1
  article-title: Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
  publication-title: Biomicrofluidics
  doi: 10.1063/1.4934713
– volume: 6
  start-page: 55
  year: 2018
  ident: ref_5
  article-title: Hybrid business models for ‘Organ-on-a-Chip’ technology: The best of both worlds
  publication-title: PharmaNutrition
  doi: 10.1016/j.phanu.2018.02.001
– volume: 30
  start-page: 996
  year: 2017
  ident: ref_106
  article-title: Multi-omics reveals that lead exposure disturbs gut microbiome development, key metabolites, and metabolic pathways
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/acs.chemrestox.6b00401
– volume: 25
  start-page: 737
  year: 2019
  ident: ref_123
  article-title: An Organ-On-A-Chip Engineered Platform to Study the Microbiota–Gut–Brain Axis in Neurodegeneration
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2019.07.006
– volume: 18
  start-page: 2686
  year: 2018
  ident: ref_8
  article-title: Microfluidic-based vascularized microphysiological systems
  publication-title: Lab Chip
  doi: 10.1039/C8LC00285A
– volume: 7
  start-page: 42296
  year: 2017
  ident: ref_83
  article-title: Functional coupling of human microphysiology systems: Intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle
  publication-title: Sci. Rep.
  doi: 10.1038/srep42296
– volume: 20
  start-page: 338
  year: 2004
  ident: ref_31
  article-title: The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors
  publication-title: Biotechnol. Prog.
  doi: 10.1021/bp034077d
– volume: 115
  start-page: 138
  year: 2019
  ident: ref_81
  article-title: Online and in situ analysis of organs-on-a-chip
  publication-title: TrAC Trends Anal. Chem.
  doi: 10.1016/j.trac.2019.04.006
– volume: 136
  start-page: 300
  year: 2018
  ident: ref_136
  article-title: Quality aspects for medical devices, quality system and certification process
  publication-title: Microchem. J.
  doi: 10.1016/j.microc.2017.04.018
– volume: 140
  start-page: 3
  year: 2019
  ident: ref_67
  article-title: Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.06.001
– volume: 5
  start-page: 14554
  year: 2015
  ident: ref_121
  article-title: Local bacteria affect the efficacy of chemotherapeutic drugs
  publication-title: Sci. Rep.
  doi: 10.1038/srep14554
– volume: 58
  start-page: 37
  year: 2018
  ident: ref_34
  article-title: Physiologically based pharmacokinetic and pharmacodynamic analysis enabled by microfluidically linked organs-on-chips
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-010716-104748
– ident: ref_133
– volume: 5
  start-page: 241
  year: 2018
  ident: ref_125
  article-title: Engineered human gastrointestinal cultures to study the microbiome and infectious diseases
  publication-title: Cell. Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2017.12.001
– ident: ref_99
– volume: 15
  start-page: 457
  year: 2018
  ident: ref_103
  article-title: Broad collateral damage of drugs against the gut microbiome
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0028-3
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Snippet Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery...
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SubjectTerms Bioengineering
Biology
Cell culture
Clinical trials
Commercialization
Cytotoxicity
Employees
Female reproductive system
gap analysis
Likert scale
Nonprofit organizations
organ-on-a-chip
Organs
Pharmaceutical industry
Polls & surveys
Product development
quality management
Quality standards
Review
Skin
Sports injuries
Technology assessment
technology-led strategy
Translation
validation
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Title Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption
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