Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development...

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Bibliographic Details
Published in:Bioengineering (Basel) Vol. 7; no. 3; p. 112
Main Authors: Allwardt, Vanessa, Ainscough, Alexander J., Viswanathan, Priyalakshmi, Sherrod, Stacy D., McLean, John A., Haddrick, Malcolm, Pensabene, Virginia
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16.09.2020
MDPI
Subjects:
Bioengineering
Biology
Cell culture
Clinical trials
Commercialization
Cytotoxicity
Employees
Female reproductive system
gap analysis
Likert scale
Nonprofit organizations
organ-on-a-chip
Organs
Pharmaceutical industry
Polls & surveys
Product development
quality management
Quality standards
Review
Skin
Sports injuries
Technology assessment
technology-led strategy
Translation
validation
United Kingdom > UK
United States > US
quality management
microphysiological systems
organotypic culture models
gap analysis
translation
technology-led strategy
body-on-a-chip
organ-on-a-chip
validation
ISSN:2306-5354, 2306-5354
Online Access:Get full text
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Summary:Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.
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ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering7030112