RB Loss Promotes Prostate Cancer Metastasis

RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine models of cancer produces a prometastatic phenotype. Gene expression analyses showed that regulation of the cell motility receptor RHAMM by the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 77; H. 4; S. 982
Hauptverfasser:	Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, Haber, Alex, Ertel, Adam, Bhardwaj, Anshul, Addya, Sankar, Williams, Noelle, Ciment, Stephen J, Cotzia, Paolo, Dean, Jeffry L, Snook, Adam, McNair, Chris, Price, Matt, Hernandez, James R, Zhao, Shuang G, Birbe, Ruth, McCarthy, James B, Turley, Eva A, Pienta, Kenneth J, Feng, Felix Y, Dicker, Adam P, Knudsen, Karen E, Den, Robert B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.02.2017
Schlagworte:	Actins - metabolism Animals Cell Line, Tumor Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - antagonists & inhibitors E2F Transcription Factors - physiology Extracellular Matrix Proteins - antagonists & inhibitors Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - physiology Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - physiology Male Mice Neoplasm Metastasis Prostatic Neoplasms - pathology Retinoblastoma Protein - physiology rho-Associated Kinases - physiology Signal Transduction - physiology
ISSN:	1538-7445, 1538-7445
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