Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AA...

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Vydané v:	Cancer research (Chicago, Ill.) Ročník 77; číslo 22; s. 6119
Hlavní autori:	Sivakumar, Smruthy, Lucas, F Anthony San, McDowell, Tina L, Lang, Wenhua, Xu, Li, Fujimoto, Junya, Zhang, Jianjun, Futreal, P Andrew, Fukuoka, Junya, Yatabe, Yasushi, Dubinett, Steven M, Spira, Avrum E, Fowler, Jerry, Hawk, Ernest T, Wistuba, Ignacio I, Scheet, Paul, Kadara, Humam
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.11.2017
Predmet:	Adenocarcinoma - genetics Adenocarcinoma - pathology Aged Disease Progression Female Gene Expression Profiling Genomics Humans Hyperplasia - genetics Lung - metabolism Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Precancerous Conditions - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics
ISSN:	1538-7445, 1538-7445
On-line prístup:	Zistit podrobnosti o prístupe
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