Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies

Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects of hyperthermia: its molecular and cellular effects and its impact on the immune system. Hyperthermia has profound effects on critical biologi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Integrative cancer therapies Jg. 23; S. 15347354241242094
Hauptverfasser: Lukácsi, Szilvia, Munkácsy, Gyöngyi, Győrffy, Balázs
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Los Angeles, CA SAGE Publications 01.01.2024
SAGE PUBLICATIONS, INC
SAGE Publishing
Schlagworte:
Adjuvant therapy
Animals
Antigen (tumor-associated)
Apoptosis
Cancer therapies
Cell cycle
Chemotherapy
Combined Modality Therapy - methods
DNA repair
Drug delivery
Drug Delivery Systems - methods
Fever
Heat shock proteins
High temperature
Humans
Hyperthermia
Hyperthermia, Induced - methods
Immune checkpoint inhibitors
Immune response
Immunotherapy
Immunotherapy - methods
Metabolic rate
Nanoparticles
Neoplasms - immunology
Neoplasms - therapy
Tumors
thermal ablation
immune system
apoptosis
fever
nanoparticle
heat shock protein
DNA repair
ISSN:1534-7354, 1552-695X, 1552-695X
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects of hyperthermia: its molecular and cellular effects and its impact on the immune system. Hyperthermia has profound effects on critical biological processes. Increased temperatures inhibit DNA repair enzymes, making cancer cells more sensitive to chemotherapy and radiation. Elevated temperatures also induce cell cycle arrest and trigger apoptotic pathways. Furthermore, hyperthermia modifies the expression of heat shock proteins, which play vital roles in cancer therapy, including enhancing immune responses. Hyperthermic treatments also have a significant impact on the body’s immune response against tumors, potentially improving the efficacy of immune checkpoint inhibitors. Mild systemic hyperthermia (39°C-41°C) mimics fever, activating immune cells and raising metabolic rates. Intense heat above 50°C can release tumor antigens, enhancing immune reactions. Using photothermal nanoparticles for targeted heating and drug delivery can also modulate the immune response. Hyperthermia emerges as a cost-effective and well-tolerated adjuvant therapy when integrated with immunotherapy. This comprehensive review serves as a valuable resource for the selection of patient-specific treatments and the guidance of future experimental studies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1534-7354
1552-695X
1552-695X
DOI:10.1177/15347354241242094