Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer

We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood. We characterized the biologic response of taxane-resistant and taxane-sensitive ovarian cancer models to a novel FAK inhibitor (VS-6063). We used reverse-...

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Vydáno v:	JNCI : Journal of the National Cancer Institute Ročník 105; číslo 19; s. 1485
Hlavní autoři:	Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J, Miyake, Takahito, Pecot, Chad V, Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B, Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y, Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong, Sood, Anil K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 02.10.2013
Témata:	Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Benzamides Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Drug Resistance, Neoplasm Female Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Kinase 1 - metabolism Humans Mice Mice, Nude Odds Ratio Organic Chemicals - pharmacology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - enzymology Paclitaxel - pharmacology Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Pyrazines Sulfonamides Xenograft Model Antitumor Assays Y-Box-Binding Protein 1 - metabolism
ISSN:	1460-2105, 1460-2105
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