CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion

The functional significance of the chemokine receptor CCR5 in human breast cancer epithelial cells is poorly understood. Here, we report that CCR5 expression in human breast cancer correlates with poor outcome. CCR5 breast cancer epithelial cells formed mammospheres and initiated tumors with >60-...

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Vydané v:	Cancer research (Chicago, Ill.) Ročník 78; číslo 7; s. 1657
Hlavní autori:	Jiao, Xuanmao, Velasco-Velázquez, Marco A, Wang, Min, Li, Zhiping, Rui, Hallgeir, Peck, Amy R, Korkola, James E, Chen, Xuelian, Xu, Shaohua, DuHadaway, James B, Guerrero-Rodriguez, Sandra, Addya, Sankar, Sicoli, Daniela, Mu, Zhaomei, Zhang, Gang, Stucky, Andres, Zhang, Xi, Cristofanilli, Massimo, Fatatis, Alessandro, Gray, Joe W, Zhong, Jiang F, Prendergast, George C, Pestell, Richard G
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2018
Predmet:	Animals Antineoplastic Agents - pharmacology Breast Neoplasms - genetics Breast Neoplasms - pathology CCR5 Receptor Antagonists - pharmacology Cell Line, Tumor Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics DNA Damage - genetics DNA Repair - immunology Epithelial Cells - metabolism Female Gene Expression Regulation, Neoplastic Humans Maraviroc - pharmacology Mice Mice, Nude Neoplasm Transplantation Neoplastic Stem Cells - metabolism Phosphatidylinositol 3-Kinases - metabolism Piperazines - pharmacology Pyrimidines - pharmacology Receptors, CCR5 - metabolism Transplantation, Heterologous
ISSN:	1538-7445, 1538-7445
On-line prístup:	Zistit podrobnosti o prístupe
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