CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion

The functional significance of the chemokine receptor CCR5 in human breast cancer epithelial cells is poorly understood. Here, we report that CCR5 expression in human breast cancer correlates with poor outcome. CCR5 breast cancer epithelial cells formed mammospheres and initiated tumors with >60-...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cancer research (Chicago, Ill.) Ročník 78; číslo 7; s. 1657
Hlavní autoři:	Jiao, Xuanmao, Velasco-Velázquez, Marco A, Wang, Min, Li, Zhiping, Rui, Hallgeir, Peck, Amy R, Korkola, James E, Chen, Xuelian, Xu, Shaohua, DuHadaway, James B, Guerrero-Rodriguez, Sandra, Addya, Sankar, Sicoli, Daniela, Mu, Zhaomei, Zhang, Gang, Stucky, Andres, Zhang, Xi, Cristofanilli, Massimo, Fatatis, Alessandro, Gray, Joe W, Zhong, Jiang F, Prendergast, George C, Pestell, Richard G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2018
Témata:	Animals Antineoplastic Agents - pharmacology Breast Neoplasms - genetics Breast Neoplasms - pathology CCR5 Receptor Antagonists - pharmacology Cell Line, Tumor Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics DNA Damage - genetics DNA Repair - immunology Epithelial Cells - metabolism Female Gene Expression Regulation, Neoplastic Humans Maraviroc - pharmacology Mice Mice, Nude Neoplasm Transplantation Neoplastic Stem Cells - metabolism Phosphatidylinositol 3-Kinases - metabolism Piperazines - pharmacology Pyrimidines - pharmacology Receptors, CCR5 - metabolism Transplantation, Heterologous
ISSN:	1538-7445, 1538-7445
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!