Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation

Oxidative stress and neuroinflammation contribute significantly to the development and progression of diabetic retinopathy. Fenofibrate has received great attention as it benefits diabetic patients by reducing retinal laser requirement. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a master...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 445; no. 1-2; pp. 105 - 115
Main Authors:	Liu, Qiuping, Zhang, Fengjun, Zhang, Xian, Cheng, Rui, Ma, Jian-xing, Yi, Jinglin, Li, Jingming
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.08.2018 Springer Springer Nature B.V
Subjects:	Activation Biochemistry Biomedical and Life Sciences Cardiology Caspase Caspase-1 Diabetes Diabetes mellitus Diabetic retinopathy Diabetics Fenofibrate Fibric acids Gene expression Glutamate-ammonia ligase Glutamine IL-1β Inflammasomes Inflammation Intercellular adhesion molecule 1 Leakage Leucine Life Sciences Medical Biochemistry Mice NRF2 protein Oncology Oxidative stress Pyrin protein Reactive oxygen species Retina Retinopathy Rodents Signaling Streptozocin Fenofibrate Diabetic retinopathy Oxidative stress Inflammasome
ISSN:	0300-8177, 1573-4919, 1573-4919
Online Access:	Get full text
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