Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy

Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger patients. The current study demonstrates that exponentially growing fibroblasts from elderly (old) male donor subjects (70, 72, and 78 years) a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 77; H. 18; S. 5054
Hauptverfasser:	Mapuskar, Kranti A, Flippo, Kyle H, Schoenfeld, Joshua D, Riley, Dennis P, Strack, Stefan, Hejleh, Taher Abu, Furqan, Muhammad, Monga, Varun, Domann, Frederick E, Buatti, John M, Goswami, Prabhat C, Spitz, Douglas R, Allen, Bryan G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.09.2017
Schlagworte:	Adult Age Factors Aged Animals Antineoplastic Agents - adverse effects Apoptosis - drug effects Apoptosis - radiation effects Cell Proliferation - drug effects Cell Proliferation - radiation effects Cells, Cultured Cisplatin - adverse effects Fibroblasts - drug effects Fibroblasts - pathology Fibroblasts - radiation effects Humans Male Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - radiation effects Mice Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - pathology Mitochondria - radiation effects Oxidative Stress Radiation, Ionizing Skin - drug effects Skin - pathology Skin - radiation effects Superoxide Dismutase - metabolism Superoxides - metabolism Young Adult
ISSN:	1538-7445, 1538-7445
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