High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy

Recently, we presented evidence that high mitochondrial ATP production is a new therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the “metabolically fittest” cancer cells from the total cell population. Importantly, ATP-high cancer cells were phenotypically the most aggr...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 11; p. 740720
Main Authors:	Fiorillo, Marco, Ózsvári, Béla, Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 15.10.2021
Subjects:	anti-oxidant capacity ATP bedaquiline cancer stem cells (CSCs) dormancy mitochondria Oncology
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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