Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease

Chronic kidney disease (CKD) subjects suffer from high risk of cardiovascular mortality, and any intervention preventing the progression of CKD may have an enormous impact on public health. In the last decade, there has been growing awareness that the gut microbiota (GM) can play a pivotal role in c...

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Vydané v:Nutrients Ročník 14; číslo 1; s. 231
Hlavní autori: Pivari, Francesca, Mingione, Alessandra, Piazzini, Giada, Ceccarani, Camilla, Ottaviano, Emerenziana, Brasacchio, Caterina, Dei Cas, Michele, Vischi, Margherita, Cozzolino, Mario Gennaro, Fogagnolo, Paolo, Riva, Antonella, Petrangolini, Giovanna, Barrea, Luigi, Di Renzo, Laura, Borghi, Elisa, Signorelli, Paola, Paroni, Rita, Soldati, Laura
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 05.01.2022
MDPI
Predmet:
Aged
Body composition
Case-Control Studies
curcumin
Curcumin - administration & dosage
Dietary Supplements
Female
Food
Gastrointestinal Microbiome - drug effects
Gut microbiota
Hemodialysis
Humans
Inflammation
interleukin-4
intestinal microorganisms
Kidney diseases
Lactobacillaceae
lipid peroxidation
Lipid Peroxidation - drug effects
Male
Metabolites
metagenomics
Microbiota
Mortality
Oxidative stress
pathogenesis
Pilot Projects
Proteins
public health
quality of life
Renal Insufficiency, Chronic - therapy
Renal Insufficiency, Chronic - urine
risk
Treatment Outcome
Uremic Toxins - urine
Italy
chronic kidney disease
Meriva
uremic toxins
inflammation
lipid peroxidation
gut microbiota
curcumin
ISSN:2072-6643, 2072-6643
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Shrnutí:Chronic kidney disease (CKD) subjects suffer from high risk of cardiovascular mortality, and any intervention preventing the progression of CKD may have an enormous impact on public health. In the last decade, there has been growing awareness that the gut microbiota (GM) can play a pivotal role in controlling the pathogenesis of systemic inflammatory state and CKD progression. To ameliorate the quality of life in CKD subjects, the use of dietary supplements has increased over time. Among those, curcumin has demonstrated significant in vitro anti-inflammatory properties. In this pilot study, 24 CKD patients and 20 healthy volunteers were recruited. CKD patients followed nutritional counselling and were supplemented with curcumin (Meriva®) for six months. Different parameters were evaluated at baseline and after 3–6 months: uremic toxins, metagenomic of GM, and nutritional, inflammatory, and oxidative status. Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation. Regarding GM, after 6 months of curcumin supplementation, Escherichia-Shigella was significantly lower, while Lachnoclostridium was significant higher. Notably, at family level, Lactobacillaceae spp. were found significantly higher in the last 3 months of supplementation. No adverse events were observed in the supplemented group, confirming the good safety profile of curcumin phytosome after long-term administration.
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These authors contributed equally to this work.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14010231