PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Cachexia is frequently accompanied by severe metabolic derangements, although the mechanisms responsible for this debilitating condition remain unclear. Pyruvate dehydrogenase kinase (PDK)4, a critical regulator of cellular energetic metabolism, was found elevated in experimental models of cancer, s...

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Vydané v:	The FASEB journal Ročník 33; číslo 6; s. 7778
Hlavní autori:	Pin, Fabrizio, Novinger, Leah J, Huot, Joshua R, Harris, Robert A, Couch, Marion E, O'Connell, Thomas M, Bonetto, Andrea
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.06.2019
Predmet:	C2C12 myotubes skeletal muscle atrophy chemotherapy mitochondria energy metabolism
ISSN:	1530-6860, 1530-6860
On-line prístup:	Zistit podrobnosti o prístupe
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