Enantioselective Synthesis of Amines: General, Efficient Iron‐Catalyzed Asymmetric Transfer Hydrogenation of Imines

In the iron age: A readily accessible, active iron catalyst serves in the straightforward, catalytic transfer hydrogenation of imines (see scheme). A series of imines are converted into chiral amines in high yields and very good enantioselectivities. This method should find broad application in the...

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Vydáno v:	Angewandte Chemie International Edition Ročník 49; číslo 44; s. 8121 - 8125
Hlavní autoři:	Zhou, Shaolin, Fleischer, Steffen, Junge, Kathrin, Das, Shoubhik, Addis, Daniele, Beller, Matthias
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Weinheim Wiley‐VCH Verlag 25.10.2010 WILEY-VCH Verlag WILEY‐VCH Verlag Wiley
Témata:	Amines - chemistry asymmetric catalysis Catalysis Chemistry Chemistry, Multidisciplinary enantioselectivity Hydrogen - chemistry imines Imines - chemistry iron catalysis Physical Sciences Science & Technology Stereoisomerism transfer hydrogenation enantioselectivity PNNP LIGAND AROMATIC KETONES COMPLEXES HYDROSILYLATION imines transfer hydrogenation asymmetric catalysis ACYCLIC IMINES HIGHLY EFFICIENT EPOXIDATION iron catalysis DERIVATIVES REDUCTIVE AMINATION STRECKER REACTION
ISSN:	1433-7851, 1521-3773, 1521-3773
On-line přístup:	Získat plný text
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Shrnutí:	In the iron age: A readily accessible, active iron catalyst serves in the straightforward, catalytic transfer hydrogenation of imines (see scheme). A series of imines are converted into chiral amines in high yields and very good enantioselectivities. This method should find broad application in the search for bioactive chiral amines.
Bibliografie:	http://dx.doi.org/10.1002/anie.201002456 BMBF istex:D3A21C3EB756CE6689B455AD84FC1DB22653C4C6 State of Mecklenburg-Western Pomerania DFG ark:/67375/WNG-1GS85CND-6 ArticleID:ANIE201002456 This work was funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, and A. Kammer, A. Koch, S. Rossmeisl, and K. Mevius for their excellent technical and analytical support. This work was funded by the State of Mecklenburg‐Western Pomerania, the BMBF, and the DFG (Leibniz prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, and A. Kammer, A. Koch, S. Rossmeisl, and K. Mevius for their excellent technical and analytical support. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773 1521-3773
DOI:	10.1002/anie.201002456