Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial

Background Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods and Results We performed a 1‐year, double‐blind, randomized control...

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Bibliographic Details
Published in:	Journal of the American Heart Association Vol. 6; no. 11
Main Authors:	MacDonald, Thomas M., Williams, Bryan, Webb, David J., Morant, Steve, Caulfield, Mark, Cruickshank, J. Kennedy, Ford, Ian, Sever, Peter, Mackenzie, Isla S., Padmanabhan, Sandosh, McCann, Gerald P., Salsbury, Jackie, McInnes, Gordon, Brown, Morris J.
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.11.2017 Wiley
Subjects:	Adolescent Adult Aged Amlodipine - administration & dosage angiotensin II receptor blocker Antihypertensive Agents - administration & dosage Blood Pressure - drug effects comparative effectiveness diuretics Dose-Response Relationship, Drug Double-Blind Method Doxazosin - administration & dosage Drug Therapy, Combination Female Follow-Up Studies Humans Hydrochlorothiazide - administration & dosage Hypertension - drug therapy Hypertension - physiopathology Losartan - administration & dosage Male Middle Aged Original Research renin treatment effectiveness Treatment Outcome Young Adult comparative effectiveness diuretics renin angiotensin II receptor blocker treatment effectiveness
ISSN:	2047-9980, 2047-9980
Online Access:	Get full text
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