N1-(2 tetrahydrofuryl)-5-fluorouracil (FT-207) in the postoperative adjuvant chemotherapy of gastric cancer. Delivery of a fat-emulsified agent to the lymph

The influence of fat emulsification of N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on lymphatic transport was studied in seven postoperative gastric cancer patients. The water-in-oil-type of emulsion of FT-207 (FT-w/o), the oil-in-water-type emulsion of FT-207 (FT-o/w) and an enteric-coated granu...

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Bibliographic Details
Published in:Cancer Vol. 57; no. 4; p. 693
Main Authors: Hanaue, H, Kurosawa, T, Kitano, Y, Miyakawa, S, Horie, F, Nemoto, A, Shikata, J
Format: Journal Article
Language:English
Published: United States 15.02.1986
Subjects:
Adult
Aged
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - metabolism
Combined Modality Therapy
Fat Emulsions, Intravenous - metabolism
Fluorouracil - metabolism
Humans
Lymph - metabolism
Male
Middle Aged
Postoperative Care
Stomach Neoplasms - drug therapy
Stomach Neoplasms - metabolism
Stomach Neoplasms - surgery
Tegafur - administration & dosage
Tegafur - metabolism
Thoracic Duct - metabolism
ISSN:0008-543X
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Summary:The influence of fat emulsification of N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on lymphatic transport was studied in seven postoperative gastric cancer patients. The water-in-oil-type of emulsion of FT-207 (FT-w/o), the oil-in-water-type emulsion of FT-207 (FT-o/w) and an enteric-coated granule of FT-207 (FT-G) each in 1-g doses, calculated in terms of FT-207, were administered orally. Lymph from a thoracic duct fistula, prepared in advance, and from the blood of a peripheral vein was collected simultaneously along a time course after administration to measure the concentrations of FT-207 and 5-fluorouracil (5-FU). For FT-w/o, FT-207, and 5-FU, concentrations were significantly higher, both in the lymph and in the blood, than those for FT-G and FT-o/w. However, no significant differences in FT-207 and 5-FU concentrations were observed between FT-o/w and FT-G. It was concluded that FT-w/o can be useful as an adjuvant chemotherapeutic drug in the postoperative treatment of gastric cancer.
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ISSN:0008-543X
DOI:10.1002/1097-0142(19860215)57:4<693::AID-CNCR2820570402>3.0.CO;2-A