KCa3.1 mediates dysfunction of tubular autophagy in diabetic kidneys via PI3k/Akt/mTOR signaling pathways

Autophagy is emerging as an important pathway in many diseases including diabetic nephropathy. It is acknowledged that oxidative stress plays a critical role in autophagy dysfunction and diabetic nephropathy and KCa3.1 blockade ameliorates diabetic renal fibrosis through inhibiting TGF-β1 signaling...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 23884
Main Authors:	Huang, Chunling, Lin, Mike Z., Cheng, Delfine, Braet, Filip, Pollock, Carol A., Chen, Xin-Ming
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.03.2016 Nature Publishing Group
Subjects:	1-Phosphatidylinositol 3-kinase 13/1 13/109 13/51 14/19 14/28 14/34 631/80 64/60 692/4022/1585/104 82/29 AKT protein Animals Autophagy Autophagy - genetics Cell Line, Transformed Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - chemically induced Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic nephropathy Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Fibrosis Gene Expression Regulation Humanities and Social Sciences Humans Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Intermediate-Conductance Calcium-Activated Potassium Channels - genetics Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Kidneys Male Mice Mice, Knockout multidisciplinary Nephropathy Nitrotyrosine Oxidative stress Phagocytosis Phagosomes - metabolism Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Science Signal Transduction siRNA Streptozocin TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Vacuoles
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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