Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus

Patients with systemic lupus erythematosus (SLE) have accelerated cardiovascular disease and dysfunctional endothelial repair mechanisms. Myeloid angiogenic cells (MACs), derived from circulating monocytes, augment vascular repair by paracrine secretion of pro-angiogenic factors. We observed that SL...

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Veröffentlicht in:	Scientific reports Jg. 6; H. 1; S. 22341
Hauptverfasser:	Reynolds, John A., Haque, Sahena, Williamson, Kate, Ray, David W., Alexander, M. Yvonne, Bruce, Ian N.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.03.2016 Nature Publishing Group
Schlagworte:	13/106 13/51 38/77 692/308/575 692/4019/592/16 692/4023/1670/1613 Adult Autoimmune diseases Calcitriol - pharmacology Cardiovascular diseases Cell Adhesion - drug effects Cell Count Cell Differentiation - drug effects Cell Movement - drug effects Chemokine CXCL10 - metabolism Down-Regulation - drug effects Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Health risks Humanities and Social Sciences Humans Immunology Interferons - metabolism Lupus Lupus Erythematosus, Systemic - metabolism Lupus Erythematosus, Systemic - physiopathology Middle Aged Models, Biological multidisciplinary Myeloid Cells - drug effects Myeloid Cells - pathology Neovascularization, Physiologic - drug effects Nitric Oxide Synthase Type III - metabolism Phenotype Science Systemic lupus erythematosus Vitamin D Vitamin D - pharmacology
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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