Cellular barcoding: A technical appraisal

Cellular barcoding involves the tagging of individual cells of interest with unique genetic heritable identifiers or barcodes and is emerging as a powerful tool to address individual cell fates on a large scale. However, as with many new technologies, diverse technical and analytical challenges have...

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Vydané v:Experimental hematology Ročník 42; číslo 8; s. 598 - 608
Hlavní autori: Naik, Shalin H., Schumacher, Ton N., Perié, Leïla
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier Inc 01.08.2014
Elsevier
Predmet:
Advanced Basic Science
Animals
Cell Lineage
Cell Separation
Cell Tracking - methods
Hematology, Oncology, and Palliative Medicine
Hematopoiesis
Humans
Life Sciences
ISSN:0301-472X, 1873-2399, 1873-2399
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Popis
Shrnutí:Cellular barcoding involves the tagging of individual cells of interest with unique genetic heritable identifiers or barcodes and is emerging as a powerful tool to address individual cell fates on a large scale. However, as with many new technologies, diverse technical and analytical challenges have emerged. Here, we review those challenges and highlight both the power and limitations of cellular barcoding. We then illustrate the contribution of cellular barcoding to the understanding of hematopoiesis and outline the future potential of this technology.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0301-472X
1873-2399
1873-2399
DOI:10.1016/j.exphem.2014.05.003