Cellular barcoding: A technical appraisal

Cellular barcoding involves the tagging of individual cells of interest with unique genetic heritable identifiers or barcodes and is emerging as a powerful tool to address individual cell fates on a large scale. However, as with many new technologies, diverse technical and analytical challenges have...

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Bibliographic Details
Published in:Experimental hematology Vol. 42; no. 8; pp. 598 - 608
Main Authors: Naik, Shalin H., Schumacher, Ton N., Perié, Leïla
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01.08.2014
Elsevier
Subjects:
Advanced Basic Science
Animals
Cell Lineage
Cell Separation
Cell Tracking - methods
Hematology, Oncology, and Palliative Medicine
Hematopoiesis
Humans
Life Sciences
ISSN:0301-472X, 1873-2399, 1873-2399
Online Access:Get full text
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Summary:Cellular barcoding involves the tagging of individual cells of interest with unique genetic heritable identifiers or barcodes and is emerging as a powerful tool to address individual cell fates on a large scale. However, as with many new technologies, diverse technical and analytical challenges have emerged. Here, we review those challenges and highlight both the power and limitations of cellular barcoding. We then illustrate the contribution of cellular barcoding to the understanding of hematopoiesis and outline the future potential of this technology.
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ISSN:0301-472X
1873-2399
1873-2399
DOI:10.1016/j.exphem.2014.05.003