Molecular digital data storage using DNA

Molecular data storage is an attractive alternative for dense and durable information storage, which is sorely needed to deal with the growing gap between information production and the ability to store data. DNA is a clear example of effective archival data storage in molecular form. In this Review...

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Veröffentlicht in:Nature reviews. Genetics Jg. 20; H. 8; S. 456 - 466
Hauptverfasser: Ceze, Luis, Nivala, Jeff, Strauss, Karin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.08.2019
Nature Publishing Group
Schlagworte:
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631/337/151/1431
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639/925/926/1047
Agriculture
Analysis
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Biotechnology
Biotechnology - methods
Cancer Research
Deoxyribonucleic acid
DNA
DNA - genetics
DNA sequencing
Gene expression
Gene Function
Human Genetics
Humans
Information storage
Information storage and retrieval
Information Storage and Retrieval - methods
Nucleotide sequencing
Review Article
ISSN:1471-0056, 1471-0064, 1471-0064
Online-Zugang:Volltext
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Zusammenfassung:Molecular data storage is an attractive alternative for dense and durable information storage, which is sorely needed to deal with the growing gap between information production and the ability to store data. DNA is a clear example of effective archival data storage in molecular form. In this Review, we provide an overview of the process, the state of the art in this area and challenges for mainstream adoption. We also survey the field of in vivo molecular memory systems that record and store information within the DNA of living cells, which, together with in vitro DNA data storage, lie at the growing intersection of computer systems and biotechnology. Throughout evolution, DNA has been the primary medium of biological information storage. In this article, Ceze, Nivala and Strauss discuss how DNA can be adopted as a storage medium for custom data, as a potential future complement to current data storage media such as computer hard disks, optical disks and tape. They discuss strategies for coding, decoding and error correction and give examples of implementation both in vitro and in vivo.
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ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-019-0125-3