Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiat...

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Bibliographic Details
Published in:NeuroImage clinical Vol. 14; no. C; pp. 719 - 725
Main Authors: Olivito, G., Cercignani, M., Lupo, M., Iacobacci, C., Clausi, S., Romano, S., Masciullo, M., Molinari, M., Bozzali, M., Leggio, M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01.01.2017
Elsevier
Subjects:
Adult
Aged
Brain Mapping
Cerebellum
Cerebellum - diagnostic imaging
Cerebral cortex
Cognition Disorders - diagnostic imaging
Cognition Disorders - etiology
Female
Functional connectivity
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Motor Disorders - diagnostic imaging
Motor Disorders - etiology
Nerve Net - diagnostic imaging
Nodes
Oxygen - blood
Radiology
Regular
Rest
Resting-state fMRI
Severity of Illness Index
Spinocerebellar Ataxias - complications
Cerebellum
Functional connectivity
Resting-state fMRI
Cerebral cortex
Nodes
ISSN:2213-1582, 2213-1582
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Summary:Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and cerebral “nodes” in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes. •A cerebellar dysfunction affects long-distance cerebral regions in SCA2 patients.•Connectivity changes affect sensorimotor and cognitive cerebello-cortical nodes.•Cerebellar symptoms may be related to altered cerebello-cerebral connectivity.
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ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2017.03.009