Demographic associations for autoantibodies in disease-free individuals of a European population

The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significa...

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Published in:Scientific reports Vol. 7; no. 1; p. 44846
Main Authors: Haller-Kikkatalo, Kadri, Alnek, Kristi, Metspalu, Andres, Mihailov, Evelin, Metsküla, Kaja, Kisand, Kalle, Pisarev, Heti, Salumets, Andres, Uibo, Raivo
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 28.03.2017
Nature Publishing Group
Subjects:
692/4017
692/499
82/1
Autoantibodies
Autoimmune diseases
Genomes
Humanities and Social Sciences
multidisciplinary
Science
ISSN:2045-2322, 2045-2322
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Abstract The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
AbstractList The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
ArticleNumber 44846
Author Mihailov, Evelin
Kisand, Kalle
Metsküla, Kaja
Pisarev, Heti
Salumets, Andres
Uibo, Raivo
Haller-Kikkatalo, Kadri
Alnek, Kristi
Metspalu, Andres
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  organization: Department of Immunology, Institute of Bio- and Translational Medicine, University of Tartu, Ravila 19, Competence Center on Health Technologies, Tiigi 61b, Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, L. Puusepa 8
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  givenname: Kristi
  surname: Alnek
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  organization: Department of Immunology, Institute of Bio- and Translational Medicine, University of Tartu, Ravila 19
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  givenname: Andres
  surname: Metspalu
  fullname: Metspalu, Andres
  organization: Estonian Genome Center, University of Tartu, Riia 23b, Institute of Molecular and Cell biology, University of Tartu, Riia 23
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  givenname: Evelin
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  surname: Kisand
  fullname: Kisand, Kalle
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  givenname: Heti
  surname: Pisarev
  fullname: Pisarev, Heti
  organization: Department of Public Health, University of Tartu, Ravila 19
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  givenname: Andres
  surname: Salumets
  fullname: Salumets, Andres
  organization: Competence Center on Health Technologies, Tiigi 61b, Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, L. Puusepa 8, Department of Biomedicine, Institute of Bio- and Translational Medicine, University of Tartu, Ravila 19, Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki
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  givenname: Raivo
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  fullname: Uibo, Raivo
  organization: Department of Immunology, Institute of Bio- and Translational Medicine, University of Tartu, Ravila 19, Competence Center on Health Technologies, Tiigi 61b
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28349935$$D View this record in MEDLINE/PubMed
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Snippet The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The...
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SubjectTerms 692/4017
692/499
82/1
Autoantibodies
Autoimmune diseases
Genomes
Humanities and Social Sciences
multidisciplinary
Science
Title Demographic associations for autoantibodies in disease-free individuals of a European population
URI https://link.springer.com/article/10.1038/srep44846
https://www.ncbi.nlm.nih.gov/pubmed/28349935
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