Demographic associations for autoantibodies in disease-free individuals of a European population

The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significa...

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Bibliographic Details
Published in:Scientific reports Vol. 7; no. 1; p. 44846
Main Authors: Haller-Kikkatalo, Kadri, Alnek, Kristi, Metspalu, Andres, Mihailov, Evelin, Metsküla, Kaja, Kisand, Kalle, Pisarev, Heti, Salumets, Andres, Uibo, Raivo
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 28.03.2017
Nature Publishing Group
Subjects:
692/4017
692/499
82/1
Autoantibodies
Autoimmune diseases
Genomes
Humanities and Social Sciences
multidisciplinary
Science
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
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These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep44846