LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p

Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 23892
Main Authors:	Bian, Zehua, Jin, Liugen, Zhang, Jiwei, Yin, Yuan, Quan, Chao, Hu, Yaling, Feng, Yuyang, Liu, Heyong, Fei, Bojian, Mao, Yong, Zhou, Leyuan, Qi, Xiaowei, Huang, Shenlin, Hua, Dong, Xing, Chungen, Huang, Zhaohui
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.04.2016 Nature Publishing Group
Subjects:	13/105 13/109 13/2 13/44 13/51 13/89 38/77 5-Fluorouracil 631/208/200 631/67/1504/1885 Animals Apoptosis Bladder cancer Cell Line, Tumor Cell Proliferation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Drug Resistance, Neoplasm - genetics Fluorouracil - chemistry Gene Expression Regulation, Neoplastic Genetic Vectors HEK293 Cells Humanities and Social Sciences Humans Male Medical prognosis Mice Mice, Nude MicroRNAs - genetics multidisciplinary Non-coding RNA Oncogenes Prognosis RNA, Long Noncoding - genetics Science Survival Transcriptional Activation Up-Regulation Urothelial carcinoma
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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