Lineage diversification, homo- and heterologous reassortment and recombination shape the evolution of chicken orthoreoviruses

The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic...

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Bibliographic Details
Published in:Scientific reports Vol. 6; no. 1; p. 36960
Main Authors: Farkas, Szilvia L., Marton, Szilvia, Dandár, Eszter, Kugler, Renáta, Gál, Bence, Jakab, Ferenc, Bálint, Ádám, Kecskeméti, Sándor, Bányai, Krisztián
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 10.11.2016
Nature Publishing Group
Subjects:
631/181/757
631/326/596/2554
Chickens
Evolution
Genetic diversity
Genomes
Geographical distribution
Humanities and Social Sciences
Immunization
multidisciplinary
Phylogenetics
Phylogeny
Recombination
Science
Topology
United States > US
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revealed similar geographic distribution and distinct evolution in case of eight studied strains that were closely related to the recently described Hungarian strain T1781. The remaining two strains showed the highest similarity with the US origin AVS-B. The topology of the phylogenetic trees of certain segments was affected by several potential homologous reassortment events between strains of Hungarian, Chinese and US origin. Analyzing the μB gene a possible heterologous reassortment event was identified in three Hungarian strains. Recombination events were detected in as much as a dozen cases implying that beside point mutations and reassorment this mechanism also plays an important role in the diversification of ARVs. All these mechanisms in concert may explain the reduced effectiveness of immunization using commercial vaccine strains.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep36960