Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies

Previous observational studies have suggested a potential relationship between osteoarthritis (OA) and the risk of cardiovascular disease (CVD), with conflicting results. We aimed to provide a systematic and quantitative summary of the association between OA and the risk of CVD. We searched Medline...

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Bibliographic Details
Published in:Scientific reports Vol. 6; no. 1; p. 39672
Main Authors: Wang, Haoran, Bai, Jing, He, Bing, Hu, Xinrong, Liu, Dongliang
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 22.12.2016
Nature Publishing Group
Subjects:
692/308/174
692/4023/1670/407
692/499
692/699/75
Arthritis
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Female
Health risk assessment
Health risks
Humanities and Social Sciences
Humans
Male
Meta-analysis
multidisciplinary
Observational studies
Observational Studies as Topic
Osteoarthritis
Osteoarthritis - epidemiology
Prospective Studies
Regression Analysis
Research Design
Retrospective Studies
Risk Factors
Science
Sensitivity analysis
Sensitivity and Specificity
Stroke - epidemiology
Studies
Treatment Outcome
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Previous observational studies have suggested a potential relationship between osteoarthritis (OA) and the risk of cardiovascular disease (CVD), with conflicting results. We aimed to provide a systematic and quantitative summary of the association between OA and the risk of CVD. We searched Medline and EMBASE to retrieve prospective and retrospective studies that reported risk estimates of the association between OA status and CVD risk. Pooled estimates were calculated by a random effects model. The search yielded 15 articles including a total of 358,944 participants, including 80,911 OA patients and 29,213 CVD patients. Overall, the risk of CVD was significantly increased by 24% (RR: 1.24, 95% CI: 1.12 to 1.37, P < 0.001) in patients with OA compared with the general population, with no significant publication bias. Furthermore, sensitivity analysis indicated that our results were robust and were not influenced by any one study. In conclusion, this meta-analysis provides strong evidence that OA is a significant risk factor for CVD.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep39672