Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent

With the increasing ability to routinely and rapidly digitize whole slide images with slide scanners, there has been interest in developing computerized image analysis algorithms for automated detection of disease extent from digital pathology images. The manual identification of presence and extent...

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Veröffentlicht in:Scientific reports Jg. 7; H. 1; S. 46450
Hauptverfasser: Cruz-Roa, Angel, Gilmore, Hannah, Basavanhally, Ajay, Feldman, Michael, Ganesan, Shridar, Shih, Natalie N.C., Tomaszewski, John, González, Fabio A., Madabhushi, Anant
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 18.04.2017
Nature Publishing Group
Schlagworte:
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631/114/1305
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Adult
Aged
Algorithms
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - diagnostic imaging
Carcinoma, Ductal, Breast - pathology
Deep Learning
Digitization
Female
Genomes
Humanities and Social Sciences
Humans
Image Interpretation, Computer-Assisted - methods
Image processing
Invasiveness
Mammography
Middle Aged
multidisciplinary
Neoplasm Invasiveness
Neural networks
Pathology
Scanners
Science
Tumor Burden
Tumors
Young Adult
ISSN:2045-2322, 2045-2322
Online-Zugang:Volltext
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Zusammenfassung:With the increasing ability to routinely and rapidly digitize whole slide images with slide scanners, there has been interest in developing computerized image analysis algorithms for automated detection of disease extent from digital pathology images. The manual identification of presence and extent of breast cancer by a pathologist is critical for patient management for tumor staging and assessing treatment response. However, this process is tedious and subject to inter- and intra-reader variability. For computerized methods to be useful as decision support tools, they need to be resilient to data acquired from different sources, different staining and cutting protocols and different scanners. The objective of this study was to evaluate the accuracy and robustness of a deep learning-based method to automatically identify the extent of invasive tumor on digitized images. Here, we present a new method that employs a convolutional neural network for detecting presence of invasive tumor on whole slide images. Our approach involves training the classifier on nearly 400 exemplars from multiple different sites, and scanners, and then independently validating on almost 200 cases from The Cancer Genome Atlas. Our approach yielded a Dice coefficient of 75.86%, a positive predictive value of 71.62% and a negative predictive value of 96.77% in terms of pixel-by-pixel evaluation compared to manually annotated regions of invasive ductal carcinoma.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep46450