Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces

No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.

Uloženo v:

Podrobná bibliografie
Vydáno v:	Chembiochem : a European journal of chemical biology Ročník 6; číslo 5; s. 821 - 824
Hlavní autoři:	Timmerman, Peter, Beld, Joris, Puijk, Wouter C, Meloen, Rob H
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Weinheim Wiley-VCH Verlag 06.05.2005 WILEY-VCH Verlag WILEY‐VCH Verlag
Témata:	Amino Acid Sequence Cyclization epitope mapping Models, Molecular Molecular Mimicry Molecular Sequence Data peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry peptidomimetics protein models Protein Structure, Tertiary Proteins - chemistry Time Factors
ISSN:	1439-4227, 1439-7633
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.
Bibliografie:	http://dx.doi.org/10.1002/cbic.200400374 ArticleID:CBIC200400374 istex:24641E24B6236844FE3C36AF2F37020C90006AFC ark:/67375/WNG-QWMKJCZL-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200400374