Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces

No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology Jg. 6; H. 5; S. 821 - 824
Hauptverfasser: Timmerman, Peter, Beld, Joris, Puijk, Wouter C, Meloen, Rob H
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim Wiley-VCH Verlag 06.05.2005
WILEY-VCH Verlag
WILEY‐VCH Verlag
Schlagworte:
Amino Acid Sequence
Cyclization
epitope mapping
Models, Molecular
Molecular Mimicry
Molecular Sequence Data
peptides
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - chemistry
peptidomimetics
protein models
Protein Structure, Tertiary
Proteins - chemistry
Time Factors
ISSN:1439-4227, 1439-7633
Online-Zugang:Volltext
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Zusammenfassung:No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.
Bibliographie:http://dx.doi.org/10.1002/cbic.200400374
ArticleID:CBIC200400374
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200400374