Clustal Omega for making accurate alignments of many protein sequences

Clustal Omega is a widely used package for carrying out multiple sequence alignment. Here, we describe some recent additions to the package and benchmark some alternative ways of making alignments. These benchmarks are based on protein structure comparisons or predictions and include a recently desc...

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Vydané v:Protein science Ročník 27; číslo 1; s. 135 - 145
Hlavní autori: Sievers, Fabian, Higgins, Desmond G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley Subscription Services, Inc 01.01.2018
John Wiley and Sons Inc
Predmet:
Alignment
benchmarking
Benchmarks
clustal omega
multiple sequence alignment
Nucleotide sequence
Protein structure
Proteins
Proteins - chemistry
Proteins - genetics
Secondary structure
Sequence Alignment - methods
Sequence Analysis, Protein - methods
Software
Tools for Protein Science
protein structure
clustal omega
benchmarking
multiple sequence alignment
ISSN:0961-8368, 1469-896X, 1469-896X
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Popis
Shrnutí:Clustal Omega is a widely used package for carrying out multiple sequence alignment. Here, we describe some recent additions to the package and benchmark some alternative ways of making alignments. These benchmarks are based on protein structure comparisons or predictions and include a recently described method based on secondary structure prediction. In general, Clustal Omega is fast enough to make very large alignments and the accuracy of protein alignments is high when compared to alternative packages. The package is freely available as executables or source code from www.clustal.org or can be run on‐line from a variety of sites, especially the EBI www.ebi.ac.uk.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0961-8368
1469-896X
1469-896X
DOI:10.1002/pro.3290