Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens

HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are polyspecific and require lipid binding for HIV...

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Veröffentlicht in:	Journal of virology Jg. 85; H. 3; S. 1340
Hauptverfasser:	Dennison, S Moses, Anasti, Kara, Scearce, Richard M, Sutherland, Laura, Parks, Robert, Xia, Shi-Mao, Liao, Hua-Xin, Gorny, Miroslaw K, Zolla-Pazner, Susan, Haynes, Barton F, Alam, S Munir
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2011
Schlagworte:	Antibodies, Monoclonal - immunology Autoantigens - immunology HIV Antibodies - immunology HIV Envelope Protein gp41 - immunology Humans Kinetics Phospholipids - immunology Protein Binding
ISSN:	1098-5514, 1098-5514
Online-Zugang:	Weitere Angaben
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