CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM

Tumors are often polyclonal due to copy number alteration (CNA) events. Through the CNA profile, we can understand the tumor heterogeneity and consistency. CNA information is usually obtained through DNA sequencing. However, many existing studies have shown a positive correlation between the gene ex...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Jg. 13; H. 5; S. 767
Hauptverfasser:	Ma, Jian, Guo, Jingjing, Fan, Zhiwei, Zhao, Weiling, Zhou, Xiaobo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 28.04.2023 MDPI
Schlagworte:	Algorithms Analysis Chromosomes Cloning Copy number copy number alteration Copy number variations DNA Copy Number Variations - genetics DNA sequencing DNA testing Gene Dosage Gene expression Genetic aspects Genomes Genomics Health aspects HMM Humans Machine learning Methods Mutation Neoplasms - genetics Neural networks Normal distribution Spatial distribution spatial transcriptome Transcriptome - genetics Transcriptomes Tumors variational graph convolutional autoencoder China HMM spatial transcriptome variational graph convolutional autoencoder copy number alteration
ISSN:	2218-273X, 2218-273X
Online-Zugang:	Volltext
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