Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress

Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin ( ANG ), the fifth member of the vertebrate-specific, secreted ribonucle...

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Bibliographic Details
Published in:	Angiogenesis (London) Vol. 16; no. 2; pp. 387 - 404
Main Authors:	Li, Shuping, Sheng, Jinghao, Hu, Jamie K., Yu, Wenhao, Kishikawa, Hiroko, Hu, Miaofen G., Shima, Kaori, Wu, David, Xu, Zhengping, Xin, Winnie, Sims, Katherine B., Landers, John E., Brown, Robert H., Hu, Guo-fu
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.04.2013 Springer Nature B.V
Subjects:	Amyotrophic lateral sclerosis Angiogenesis Angiogenin Animals Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research Cardiology Cell Biology Cell Line Cell survival Coding Cortex Degeneration Differentiation DNA Primers Embryo cells Humans In Situ Hybridization Metabolism Mice Missense mutation Motor neurons Neovascularization, Physiologic Neurofilaments Neurogenesis Neuroprotection Oncology Ophthalmology Original Paper Polymerase Chain Reaction Polymorphism, Genetic Promoters Ribonuclease Ribonucleases - genetics Ribonucleases - metabolism RNA processing Single-nucleotide polymorphism Stem cells Stress Superoxide dismutase Angiogenesis Neuroprotection Angiogenin Ribonuclease 4 Amyotrophic lateral sclerosis (ALS) Neurogenesis
ISSN:	0969-6970, 1573-7209, 1573-7209
Online Access:	Get full text
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