TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma

Purpose To evaluate the prevalence of two recurrent somatic mutations (−124 C>T and −146 C>T) within the promoter of the gene encoding telomerase reverse transcriptase ( TERT ) as well as their relationship with TERT level, telomeres length, and outcome in patients with head and neck squamous...

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Bibliographic Details
Published in:	Journal of cancer research and clinical oncology Vol. 146; no. 2; pp. 381 - 389
Main Authors:	Boscolo-Rizzo, Paolo, Giunco, Silvia, Rampazzo, Enrica, Brutti, Martina, Spinato, Giacomo, Menegaldo, Anna, Stellin, Marco, Mantovani, Monica, Bandolin, Luigia, Rossi, Marco, Del Mistro, Annarosa, Tirelli, Giancarlo, Dei Tos, Angelo Paolo, Guerriero, Angela, Niero, Monia, Da Mosto, Maria Cristina, Polesel, Jerry, De Rossi, Anita
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020 Springer Nature B.V
Subjects:	Adult Aged Aged, 80 and over Cancer Research Cohort Studies Female Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Hematology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Mucosa Mutation Mutation hot spots Oncology Oral cavity Original Article – Cancer Research Original – Cancer Research Polymerase chain reaction Promoter Regions, Genetic Prospective Studies RNA-directed DNA polymerase Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Survival Analysis Telomerase Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Telomere - genetics Telomere - metabolism Telomere - pathology Telomeres Tumors Yeast Promoter Head and neck squamous cell carcinoma Telomerase reverse transcriptase Mutation Telomere
ISSN:	0171-5216, 1432-1335, 1432-1335
Online Access:	Get full text
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