Genome- and transcriptome-wide association meta-analysis reveals new insights into genes affecting coronary and peripheral artery disease

A low ankle-brachial Index (ABI) is an established condition for peripheral artery disease (PAD) and cardiovascular disease risk. The search for genetic determinants of the ankle-brachial index (ABI) is important to better understand molecular patho-cmechanisms of PAD and its commonalities with card...

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Veröffentlicht in:	PloS one Jg. 20; H. 11; S. e0335513
Hauptverfasser:	Rode, Michael, Rosolowski, Maciej, Horn, Katrin, Henger, Sylvia, Teren, Andrej, Wirkner, Kerstin, Thiery, Joachim, Loeffler, Markus, Pott, Janne, Kirsten, Holger, Scholz, Markus
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 18.11.2025 Public Library of Science (PLoS)
Schlagworte:	Aged Analysis Ankle Ankle Brachial Index Arteriosclerosis Association analysis Atherosclerosis Blood Blood pressure Calcification Cardiovascular disease Cardiovascular diseases Cellular stress response Cholesterol Chronic illnesses Coronary artery disease Coronary Artery Disease - genetics Coronary heart disease Coronary vessels Data collection Degranulation Dystrophin Female Gene expression Gene set enrichment analysis Genes Genetic factors Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genomic analysis Genomics Health aspects Health risks Heart attacks Heart diseases Homeostasis Humans Interferon Leukocytes (neutrophilic) Male Measurement Meta-analysis Middle Aged Mortality Pathophysiology Peripheral Arterial Disease - genetics Polymorphism, Single Nucleotide Quality control Signal transduction Therapeutic targets Transcriptome Transcriptomes Vascular diseases Vein & artery diseases Germany
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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