Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo

Somites are transient, mesodermally derived structures that give rise to a number of different cell types within the vertebrate embryo. To achieve this, somitic cells are partitioned into lineage-restricted domains, whose fates are determined by signals secreted from adjacent tissues. While the mole...

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Bibliographic Details
Published in:Developmental cell Vol. 12; no. 2; p. 207
Main Authors: Hollway, Georgina E, Bryson-Richardson, Robert J, Berger, Silke, Cole, Nicholas J, Hall, Thomas E, Currie, Peter D
Format: Journal Article
Language:English
Published: United States 01.02.2007
Subjects:
Animals
Body Patterning - physiology
Cell Compartmentation
Cell Lineage
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - embryology
Gene Expression Regulation, Developmental
Muscle Cells - cytology
Muscle Cells - metabolism
PAX7 Transcription Factor - metabolism
Rotation
Signal Transduction
Somites - cytology
Somites - physiology
Stem Cells - cytology
Stem Cells - metabolism
Zebrafish - embryology
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
ISSN:1534-5807
Online Access:Get more information
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Summary:Somites are transient, mesodermally derived structures that give rise to a number of different cell types within the vertebrate embryo. To achieve this, somitic cells are partitioned into lineage-restricted domains, whose fates are determined by signals secreted from adjacent tissues. While the molecular nature of many of the inductive signals that trigger formation of different cell fates within the nascent somite has been identified, less is known about the processes that coordinate the formation of the subsomitic compartments from which these cells arise. Utilizing a combination of vital dye-staining and lineage-tracking techniques, we describe a previously uncharacterized, lineage-restricted compartment of the zebrafish somite that generates muscle progenitor cells for the growth of appendicular, hypaxial, and axial muscles during development. We also show that formation of this compartment occurs via whole-somite rotation, a process that requires the action of the Sdf family of secreted cytokines.
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ISSN:1534-5807
DOI:10.1016/j.devcel.2007.01.001