Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum

During the last few decades, efforts to increase the safety of blood and blood products have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The evolution of these approaches and the achieved increase in safety is shown for the last 25 years in Switzerland. In...

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Vydané v:	Viruses Ročník 14; číslo 12; s. 2611
Hlavní autori:	Niederhauser, Christoph, Tinguely, Caroline, Stolz, Martin, Vock, Michael, El Dusouqui, Soraya Amar, Gowland, Peter
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 23.11.2022 MDPI
Predmet:	Algorithms Antibodies Antigens Bacterial infections blood Blood & organ donations blood donation Blood Donors Blood Safety Blood transfusions evolution evolution of the screening strategies Hepatitis B Hepatitis B virus - genetics Hepatitis C Hepatitis C - epidemiology HIV HIV Infections - prevention & control Human immunodeficiency virus Humans Infections Infectious diseases Mass Screening - methods Nucleic Acid Amplification Techniques nucleic acid amplification technology (NAT) nucleic acids pathogens Safety safety of labile blood components Serology Switzerland Switzerland - epidemiology Syphilis Testing laboratories Treponema pallidum Treponema pallidum - genetics Viruses Switzerland nucleic acid amplification technology (NAT) evolution of the screening strategies safety of labile blood components blood donation
ISSN:	1999-4915, 1999-4915
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Popis
Shrnutí:	During the last few decades, efforts to increase the safety of blood and blood products have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The evolution of these approaches and the achieved increase in safety is shown for the last 25 years in Switzerland. In detail, the prevalences and incidences of the infection disease and the theoretical estimated residual risks (RR) of these blood-borne infections are presented. Prevalences, incidences and, in particular, the RR have decreased considerably over the last 25 years. This was achieved primarily by the adoption of strict criteria for the selection of blood donors, refined questionnaires, the introduction of increasingly sensitive serological screening tests and the implementation of nucleic acid testing (NAT) for these blood-borne pathogens. These NAT assays have significantly shortened the window period between infection and the first detection of the infectious agent in the blood of an infected individual. A form of “real life” comparison or confirmation is provided by the reported lookback procedures (LBP) and the haemovigilance data of the Swiss competent authority, Swissmedic. These data are in agreement, and thus support the very low prevalences, incidences and RR.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v14122611