DNA damage-induced cell death： lessons from the central nervous system

DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well underst...

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Bibliographic Details
Published in:	Cell research Vol. 18; no. 1; pp. 17 - 26
Main Authors:	Borges, Helena Lobo, Linden, Rafael, Wang, Jean YJ
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2008 Nature Publishing Group
Subjects:	Animals Apoptosis - genetics Apoptosis - radiation effects Biomedical and Life Sciences Caspases - metabolism Caspases - physiology Cell Biology Cell death Cell Death - genetics Cell Death - radiation effects Central nervous system Deoxyribonucleic acid DNA DNA Damage - physiology DNA Fragmentation Enzyme Activation - physiology Enzyme Activation - radiation effects Humans Ionizing radiation Life Sciences Models, Biological Mortality Radiation Dosage Radiation Injuries, Experimental - genetics Radiation, Ionizing Retina - growth & development Retina - radiation effects review 死亡过程神经系统脱氧核糖核酸 apoptosis neonatal retina ATM phosphorylation ionizing radiation neuroblasts p53
ISSN:	1001-0602, 1748-7838, 1748-7838
Online Access:	Get full text
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