DNA damage-induced cell death： lessons from the central nervous system

DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well underst...

Full description

Saved in:

Bibliographic Details
Published in:	Cell research Vol. 18; no. 1; pp. 17 - 26
Main Authors:	Borges, Helena Lobo, Linden, Rafael, Wang, Jean YJ
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2008 Nature Publishing Group
Subjects:	Animals Apoptosis - genetics Apoptosis - radiation effects Biomedical and Life Sciences Caspases - metabolism Caspases - physiology Cell Biology Cell death Cell Death - genetics Cell Death - radiation effects Central nervous system Deoxyribonucleic acid DNA DNA Damage - physiology DNA Fragmentation Enzyme Activation - physiology Enzyme Activation - radiation effects Humans Ionizing radiation Life Sciences Models, Biological Mortality Radiation Dosage Radiation Injuries, Experimental - genetics Radiation, Ionizing Retina - growth & development Retina - radiation effects review 死亡过程神经系统脱氧核糖核酸 apoptosis neonatal retina ATM phosphorylation ionizing radiation neuroblasts p53
ISSN:	1001-0602, 1748-7838, 1748-7838
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage： integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation （IR） in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.
AbstractList	DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage： integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation （IR） in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development. DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development. DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways . In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development. DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.
Author	Helena Lobo Borges Rafael Linden Jean YJ Wang
AuthorAffiliation	Division of Hematology/Oncology, Moores Cancer Center, Department of Medicine, University of California, San Diego, 3855 Health Sciences, La Jolla, CA 92093-0820, USA; Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Cidade Universitaria, 21940-590 Rio de Janeiro, Brazil; Instiuto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Cidade Universiteria, 21940-590 Rio de Janeiro, Brazil
AuthorAffiliation_xml	– name: 3 Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária, 21940-590 Rio de Janeiro, Brazil – name: 2 Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária, 21940-590 Rio de Janeiro, Brazil – name: 1 Division of Hematology/Oncology, Moores Cancer Center, Department of Medicine, University of California, San Diego, 3855 Health Sciences, La Jolla, CA 92093-0820, USA
Author_xml	– sequence: 1 givenname: Helena Lobo surname: Borges fullname: Borges, Helena Lobo organization: Division of Hematology/Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária – sequence: 2 givenname: Rafael surname: Linden fullname: Linden, Rafael organization: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária – sequence: 3 givenname: Jean YJ surname: Wang fullname: Wang, Jean YJ email: jywang@ucsd.edu organization: Division of Hematology/Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18087290$$D View this record in MEDLINE/PubMed
BookMark	eNqFkctu1TAQhi1URC-wYo8ikNhADmMnvmSDVJVLkSrYwNpynMk5Lond2kmlvgrPwjvxCjicA5QKxGos-Zt__pn_kOz54JGQhxRWFCr1wsYVA5ArSuEOOaCyVqVUldrLbwBaggC2Tw5TOgdgvOb0HtmnCpRkDRyQ01fvj4vOjGaNpfPdbLErLA5D0aGZNt--fikGTCn4VPQxjMW0wfztp2iGwmO8CnMq0nWacLxP7vZmSPhgV4_IpzevP56clmcf3r47OT4rLQc2lVYZobC1tbR5PjVMNbgUwKZtQIquslBbaK0AqnpuK9bQru0a2yOXlmN1RF5udS_mdsRuZ0ZfRDeaeK2DcfrPH-82eh2uNBNMiIpngac7gRguZ0yTHl1aVjYe8zpa5sGSK_lfkIGoAaDK4JNb4HmYo89X0BSY5LVQP6hHN43_cvwziww82wI2hpQi9r8R0EvS2ka9JK1z0pmmt2jrJjO5sGzthn_0PN_2pKzs1xhvGv0b_ng3YhP8-jJ36NbYz70bMF-TM6BAq-9p2cXI
CitedBy_id	crossref_primary_10_1074_jbc_RA120_013726 crossref_primary_10_1016_j_jbior_2024_101013 crossref_primary_10_1073_pnas_0909218106 crossref_primary_10_1038_s41477_020_00809_6 crossref_primary_10_1111_febs_16414 crossref_primary_10_3390_molecules27185757 crossref_primary_10_1038_s41598_020_70796_3 crossref_primary_10_1016_j_bbagrm_2019_05_006 crossref_primary_10_1158_0008_5472_CAN_20_2199 crossref_primary_10_1002_ange_202309043 crossref_primary_10_1016_j_jddst_2024_106186 crossref_primary_10_1126_scisignal_aat0229 crossref_primary_10_3390_cancers12020350 crossref_primary_10_1016_j_clnu_2020_10_037 crossref_primary_10_37549_ARO_D_25_00003P1 crossref_primary_10_1007_s11373_008_9253_z crossref_primary_10_1007_s10967_025_10212_0 crossref_primary_10_1158_0008_5472_CAN_09_1562 crossref_primary_10_1016_j_jphotobiol_2013_06_003 crossref_primary_10_1016_j_xpro_2025_103921 crossref_primary_10_3892_ijo_2018_4306 crossref_primary_10_1002_mp_14034 crossref_primary_10_1016_j_chemosphere_2019_125614 crossref_primary_10_1016_j_nimb_2023_06_004 crossref_primary_10_1016_j_fct_2016_12_003 crossref_primary_10_1007_s10495_014_1040_x crossref_primary_10_1016_j_canlet_2020_03_006 crossref_primary_10_1016_j_tice_2020_101450 crossref_primary_10_1002_ptr_4720 crossref_primary_10_1016_j_dnarep_2014_01_013 crossref_primary_10_3389_fmed_2023_1197846 crossref_primary_10_1016_j_toxlet_2024_02_008 crossref_primary_10_1016_j_intimp_2019_105847 crossref_primary_10_1038_cddis_2015_235 crossref_primary_10_1016_j_mrfmmm_2012_03_006 crossref_primary_10_1016_j_bbrc_2019_04_189 crossref_primary_10_3390_toxics12110774 crossref_primary_10_1269_jrr_10056 crossref_primary_10_1080_03601234_2014_894777 crossref_primary_10_3390_v10080393 crossref_primary_10_4103_jcrt_JCRT_844_20 crossref_primary_10_1080_13102818_2020_1726208 crossref_primary_10_15252_embr_202256112 crossref_primary_10_1002_anie_202309043 crossref_primary_10_1038_s41598_018_26117_w crossref_primary_10_52711_0974_360X_2024_00809 crossref_primary_10_1039_c3cp51129d crossref_primary_10_1002_em_22118 crossref_primary_10_1016_j_mrgentox_2021_503352 crossref_primary_10_1016_j_tiv_2023_105638 crossref_primary_10_1038_s41598_017_06851_3 crossref_primary_10_1016_j_chemosphere_2018_07_138 crossref_primary_10_1016_j_dnarep_2024_103726 crossref_primary_10_3389_fimmu_2025_1541209 crossref_primary_10_3389_fimmu_2022_1101429 crossref_primary_10_3389_fncel_2021_673132 crossref_primary_10_1007_s12015_025_10886_9 crossref_primary_10_1038_s41598_018_29430_6 crossref_primary_10_3390_cancers14205071 crossref_primary_10_1128_jvi_01087_23 crossref_primary_10_1186_s12931_023_02366_w crossref_primary_10_3724_abbs_2025130 crossref_primary_10_3389_fonc_2022_837373 crossref_primary_10_1007_s00280_021_04337_8 crossref_primary_10_1371_journal_pone_0017918 crossref_primary_10_3389_fmars_2019_00147 crossref_primary_10_1146_annurev_arplant_043015_111902 crossref_primary_10_3390_cancers13184575 crossref_primary_10_1016_j_ejmech_2018_06_026 crossref_primary_10_3390_ijms20051073 crossref_primary_10_1177_09636897221108705 crossref_primary_10_1080_09553002_2019_1665206 crossref_primary_10_1242_jcs_200782 crossref_primary_10_3389_fmolb_2021_629888 crossref_primary_10_1038_onc_2012_556 crossref_primary_10_1016_j_freeradbiomed_2021_11_009 crossref_primary_10_3389_fonc_2021_704664 crossref_primary_10_3390_ijms21186521 crossref_primary_10_1016_j_lfs_2022_120609 crossref_primary_10_1016_j_jcyt_2016_08_008 crossref_primary_10_1016_j_sbi_2012_11_008 crossref_primary_10_1016_j_cell_2016_10_023 crossref_primary_10_1038_s41598_020_77159_y crossref_primary_10_4162_nrp_2021_15_1_12 crossref_primary_10_1016_j_bbrc_2013_09_129 crossref_primary_10_1177_0976500X241312720 crossref_primary_10_1016_j_yexcr_2025_114688 crossref_primary_10_1007_s12672_025_02054_9 crossref_primary_10_1016_j_yao_2021_02_001 crossref_primary_10_1038_s41419_018_1106_8 crossref_primary_10_1186_s13058_023_01758_6 crossref_primary_10_1002_ijc_33038 crossref_primary_10_1038_s41419_019_1317_7 crossref_primary_10_3390_cancers11040498 crossref_primary_10_3390_antiox11091728 crossref_primary_10_1016_j_jneuroim_2010_04_009 crossref_primary_10_3389_fcell_2020_00717 crossref_primary_10_1088_1361_6528_ad823f crossref_primary_10_3390_ijms25052754 crossref_primary_10_3892_mmr_2024_13317 crossref_primary_10_1038_s41598_017_09779_w crossref_primary_10_1093_jjco_hyt138 crossref_primary_10_1534_genetics_119_302051 crossref_primary_10_1016_j_cbi_2018_04_008 crossref_primary_10_3892_ijo_2018_4642
Cites_doi	10.1111/j.1600-065X.2006.00430.x 10.1016/j.yexcr.2006.06.009 10.1046/j.1460-9568.1999.00868.x 10.1016/0014-4827(62)90311-7 10.1016/S1535-6108(03)00244-7 10.1023/B:APPT.0000045786.98031.1d 10.1073/pnas.97.2.889 10.1016/j.ceb.2007.02.009 10.1038/sj.cdd.4400527 10.1038/35037717 10.1038/nrc2087 10.1016/j.molmed.2006.07.007 10.1016/j.drup.2006.04.002 10.1523/JNEUROSCI.21-17-06687.2001 10.1006/excr.1995.1397 10.4161/cc.6.6.3990 10.1128/MCB.22.8.2441-2449.2002 10.2174/138161206777947704 10.1128/MCB.19.2.1202 10.1038/sj.cdd.4401539 10.1161/01.STR.0000257802.82826.a7 10.1038/sj.cdd.4401486 10.1016/j.critrevonc.2007.04.003 10.1093/rpd/ncl495 10.1016/0006-8993(92)91599-A 10.1016/j.nec.2006.10.010 10.4161/cc.6.8.4180 10.1038/ng1293 10.1038/nature05939 10.1016/S1097-2765(00)00136-2 10.1128/MCB.00062-06 10.1038/sj.cdd.4402060 10.1038/sj.onc.1210337 10.1667/RR3421.1 10.1126/science.280.5366.1089 10.1073/pnas.220252297 10.2174/187152006778699086 10.1242/jcs.00210 10.3171/jns.2003.98.2.0378 10.1002/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S 10.1016/j.biocel.2004.10.013 10.1101/gad.1199904 10.1016/S0960-9822(01)00534-6 10.1126/science.1096645 10.1016/S1350-9462(98)00020-2 10.1038/sj.cdd.4401366 10.1016/j.ccr.2007.08.033 10.1038/sj.cdd.4401976 10.1002/jnr.10738 10.1146/annurev.genet.40.051206.105231 10.1016/j.cell.2007.08.005 10.1016/j.bbabio.2006.06.014 10.1016/j.gde.2007.05.009 10.4161/cc.6.4.3886 10.1111/j.1432-1033.2004.04084.x 10.1080/109374001301419737 10.1038/416560a 10.1073/pnas.1635435100 10.1038/356397a0 10.1016/S0014-4827(02)00027-7 10.1016/j.neuroscience.2006.07.026 10.1038/sj.embor.embor901 10.1038/nrc2169 10.1126/science.1059108 10.1016/S0065-3233(04)69004-8 10.1016/S1535-6108(03)00249-6 10.1016/S0300-483X(02)00457-2 10.1016/0016-5085(95)90335-6 10.1093/emboj/cdf506 10.1007/s10735-006-9043-8 10.1016/j.molcel.2007.05.017 10.1038/sj.onc.1210157 10.1101/gad.14.3.289 10.1242/jcs.112.23.4315
ContentType	Journal Article
Copyright	Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008 Copyright Nature Publishing Group Jan 2008
Copyright_xml	– notice: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008 – notice: Copyright Nature Publishing Group Jan 2008
DBID	2RA 92L CQIGP W94 WU4 ~WA AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM
DOI	10.1038/cr.2007.110
DatabaseName	维普期刊资源整合服务平台中文科技期刊数据库-CALIS站点维普中文期刊数据库中文科技期刊数据库-自然科学中文科技期刊数据库-自然科学-生物科学中文科技期刊数据库- 镜像站点 CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Local Electronic Collection Information ProQuest : Biological Science Collection journals [unlimited simultaneous users] ProQuest Central (subscription) Natural Science Collection ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest Central Student MEDLINE - Academic MEDLINE Neurosciences Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	DNA damage-induced cell death： lessons from the central nervous system
EISSN	1748-7838
EndPage	26
ExternalDocumentID	PMC2626635 2718525041 18087290 10_1038_cr_2007_110 26520101
Genre	Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: R01 CA043054 – fundername: NCI NIH HHS grantid: R37 CA043054
GroupedDBID	--- -01 -0A -Q- -SA -S~ 0R~ 29B 2B. 2C. 2RA 2WC 36B 39C 3V. 4.4 53G 5GY 5VR 5XA 5XB 5XL 6J9 70F 7X7 88E 8FE 8FH 8FI 8FJ 92E 92I 92L 92M 92Q 93N 9D9 9DA AADWK AANZL AAPBV AAWBL AAYJO AAZLF ABAWZ ABDEU ABGIJ ABUWG ACBMV ACBRV ACBYP ACGFO ACGFS ACIGE ACIWK ACKTT ACPRK ACRQY ACTTH ACVWB ADBBV ADFRT ADHDB ADMDM ADQMX ADYYL AEDAW AEFTE AEJRE AENEX AEXYK AFKRA AFRAH AFSHS AFUIB AGEZK AGGBP AGHAI AHMBA AHSBF AILAN AJDOV AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMRJV AMYLF AOIJS AXYYD BAWUL BBAFP BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C1A CAG CAJEA CAJUS CCEZO CCVFK CDYEO CHBEP CIAHI COF CQIGP CS3 CW9 DIK DNIVK DU5 E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FA0 FDQFY FERAY FIZPM FSGXE FYUFA GX1 HCIFZ HYE HZ~ JSO JUIAU JZLTJ KQ8 LK8 M1P M7P NAO NQJWS NYICJ O9- OK1 P2P PQEST PQQKQ PQUKI PROAC PSQYO Q-- Q-0 R-A RNS RNT RNTTT RPM RT1 S.. SNX SNYQT SRMVM SV3 SWTZT T8Q TAOOD TBHMF TCJ TDRGL TGP TR2 U1F U1G U5A U5K UKHRP W94 WFFXF WU4 XSB ~88 ~WA 406 AACDK AAHBH AASML AATNV AAXDM AAYZH ABAKF ABJNI ABZZP ACAOD ACMJI ACZOJ AEFQL AEMSY AESKC AEUYN AEVLU AFBBN AGQEE AIGIU ALIPV CCPQU DPUIP FIGPU HMCUK IWAJR LGEZI LOTEE NADUK NXXTH ROL SOHCF SOJ AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFFHD AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PRINS RC3 PUEGO 7X8 5PM
ID	FETCH-LOGICAL-c502t-c8a68ebc47c2901a289e01a20e9b9076d3c04c0bc6018f5c3291dbd9cfe57c5e3
IEDL.DBID	M7P
ISICitedReferencesCount	127
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000252920000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1001-0602 1748-7838
IngestDate	Tue Nov 04 02:01:15 EST 2025 Thu Oct 02 11:34:18 EDT 2025 Sun Sep 28 04:43:17 EDT 2025 Sat Nov 29 14:32:27 EST 2025 Mon Jul 21 05:44:56 EDT 2025 Sat Nov 29 05:46:43 EST 2025 Tue Nov 18 22:02:30 EST 2025 Fri Feb 21 02:38:09 EST 2025 Thu Nov 24 20:32:41 EST 2022
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	apoptosis neonatal retina ATM phosphorylation ionizing radiation neuroblasts p53
Language	English
License	http://www.springer.com/tdm
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c502t-c8a68ebc47c2901a289e01a20e9b9076d3c04c0bc6018f5c3291dbd9cfe57c5e3
Notes	Q523 apoptosis, ATM, ionizing radiation, neonatal retina, neuroblasts, p53, phosphorylation 31-1568/Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Review-3
OpenAccessLink	https://www.nature.com/articles/cr2007110.pdf
PMID	18087290
PQID	1027546803
PQPubID	536307
PageCount	10
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_2626635 proquest_miscellaneous_70187587 proquest_miscellaneous_20640003 proquest_journals_1027546803 pubmed_primary_18087290 crossref_primary_10_1038_cr_2007_110 crossref_citationtrail_10_1038_cr_2007_110 springer_journals_10_1038_cr_2007_110 chongqing_backfile_26520101
PublicationCentury	2000
PublicationDate	2008-01-01
PublicationDateYYYYMMDD	2008-01-01
PublicationDate_xml	– month: 01 year: 2008 text: 2008-01-01 day: 01
PublicationDecade	2000
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Cell research
PublicationTitleAbbrev	Cell Res
PublicationTitleAlternate	Cell Research
PublicationYear	2008
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Kumar (CR19) 2007; 14 Chao, Herr, Chun, Xu (CR49) 2006; 25 Chen, Zhao (CR18) 1998; 282 He, He, Lim (CR32) 2007; 447 Lee, Chong, McKinnon (CR72) 2001; 21 Short, Bourne, Martindale, Woodcock, Jackson (CR15) 2005; 164 Wei, Zong, Cheng (CR62) 2001; 292 Roos, Kaina (CR3) 2006; 12 Rich, Allen, Wyllie (CR1) 2000; 407 Lavin, Kozlov (CR9) 2007; 6 Herzog, Chong, Kapsetaki, Morgan, McKinnon (CR50) 1998; 280 Lahav, Rosenfeld, Sigal (CR31) 2004; 36 Kim, Emi, Tanabe (CR37) 2005; 14 Festjens, Vanden Berghe, Vandenabeele (CR43) 2006; 1757 D'Sa, Klocke, Cecconi (CR63) 2003; 74 Cande, Cecconi, Dessen, Kroemer (CR34) 2002; 115 Raver-Shapira, Marciano, Meiri (CR33) 2007; 26 Hahn, Lindsten, Lyubarsky (CR64) 2004; 11 Lu, Ma, Nguyen, Jones, Oren, Donehower (CR29) 2007; 12 Wu, Earle, Saito, Anderson, Appella, Xu (CR66) 2002; 22 Mollinedo, Gajate (CR76) 2006; 9 Borges, Linden (CR55) 1999; 112 Proskuryakov, Konoplyannikov, Gabai (CR42) 2003; 283 Shieh, Ahn, Tamai, Taya, Prives (CR67) 2000; 14 Michod, Widmann (CR5) 2007; 63 Jeggo, Lobrich (CR8) 2006; 122 Bartek, Lukas (CR10) 2007; 19 Yu, Zhang (CR24) 2003; 4 Bredesen (CR41) 2007; 38 Borges, Chao, Xu, Linden, Wang (CR48) 2004; 11 Coppola, Nosseri, Maresca, Ghibelli (CR45) 1995; 221 Watson, Askew, Benson (CR46) 1995; 109 Ferrer, Serrano, Rivera, Olive, Zujar, Graus (CR54) 1993; 86 Ferguson, Griffith (CR77) 2006; 213 Boutros, Lobjois, Ducommun (CR12) 2007; 7 Yu, Alva, Su (CR40) 2004; 304 Truong, Sun, Doorly, Wang, Schwartz (CR78) 2003; 100 Schumacher, Schertel, Wittenburg (CR22) 2005; 12 Kerr (CR36) 2002; 181–182 Linden, Rehen, Chiarini (CR52) 1999; 18 Mansilla, Bataller, Portugal (CR14) 2006; 6 Lorenzo, Susin, Penninger, Kroemer (CR35) 1999; 6 Rudolph (CR11) 2007; 7 Takai, Naka, Okada (CR65) 2002; 21 Rehen, Neves, Fragel-Madeira, Britto, Linden (CR74) 1999; 11 Borges, Hunton, Wang (CR47) 2007; 26 Chong, Murray, Gosink (CR60) 2000; 97 Linden, Rehen, Chiarini (CR73) 1996; 56 Domingos, Steller (CR20) 2007; 17 Jeffers, Parganas, Lee (CR59) 2003; 4 Deyoung, Ellisen (CR28) 2007; 26 Hurley, Bunz (CR17) 2007; 6 Raff (CR51) 1992; 356 Ferrer (CR53) 1992; 588 Bentle, Bey, Dong, Reinicke, Boothman (CR4) 2006; 37 Zong, Ditsworth, Bauer, Wang, Thompson (CR44) 2004; 18 Bewick, Lafrenie (CR79) 2006; 12 Abu-Qare, Abou-Donia (CR25) 2001; 4 Chao, Saito, Anderson, Appella, Xu (CR70) 2000; 97 Schumacher, Hofmann, Boulton, Gartner (CR21) 2001; 11 Fujita (CR75) 1962; 28 Yao, Komata, Kondo, Kanzawa, Kondo, Germano (CR39) 2003; 98 Blank, Shiloh (CR2) 2007; 6 Chao, Wu, Mazur (CR71) 2006; 26 Harrison, Haber (CR13) 2006; 40 Lou, Chen (CR16) 2006; 312 Salinas, Maldonado, Navarro (CR23) 2006; 13 Ben-Porath, Weinberg (CR7) 2005; 37 Mizumatsu, Monje, Morhardt, Rola, Palmer, Fike (CR57) 2003; 63 Wang, Cho (CR6) 2004; 69 Assuncao Guimaraes, Linden (CR38) 2004; 271 Lee, McKinnon (CR56) 2007; 145 Lindsten, Ross, King (CR61) 2000; 6 Flores, Tsai, Crowley (CR27) 2002; 416 Fike, Rola, Limoli (CR58) 2007; 18 Liu, Scolnick, Trievel (CR69) 1999; 19 Aylon, Oren (CR30) 2007; 130 Hajra, Liu (CR26) 2004; 9 Craig, Scott, Burch, Smith, Ball, Hupp (CR68) 2003; 4 C Cande (BFcr2007110_CR34) 2002; 115 G Lahav (BFcr2007110_CR31) 2004; 36 Y Lee (BFcr2007110_CR56) 2007; 145 KM Hajra (BFcr2007110_CR26) 2004; 9 R Kim (BFcr2007110_CR37) 2005; 14 C Chao (BFcr2007110_CR71) 2006; 26 PJ Hurley (BFcr2007110_CR17) 2007; 6 S Kumar (BFcr2007110_CR19) 2007; 14 LS Salinas (BFcr2007110_CR23) 2006; 13 T Rich (BFcr2007110_CR1) 2000; 407 R Boutros (BFcr2007110_CR12) 2007; 7 B Schumacher (BFcr2007110_CR22) 2005; 12 ER Flores (BFcr2007110_CR27) 2002; 416 L He (BFcr2007110_CR32) 2007; 447 JR Fike (BFcr2007110_CR58) 2007; 18 SK Rehen (BFcr2007110_CR74) 1999; 11 MJ Chong (BFcr2007110_CR60) 2000; 97 DE Bredesen (BFcr2007110_CR41) 2007; 38 J Bartek (BFcr2007110_CR10) 2007; 19 AW Abu-Qare (BFcr2007110_CR25) 2001; 4 SY Shieh (BFcr2007110_CR67) 2000; 14 I Ben-Porath (BFcr2007110_CR7) 2005; 37 Y Aylon (BFcr2007110_CR30) 2007; 130 C Chao (BFcr2007110_CR49) 2006; 25 MF Lavin (BFcr2007110_CR9) 2007; 6 Y Lee (BFcr2007110_CR72) 2001; 21 J Yu (BFcr2007110_CR24) 2003; 4 MC Wei (BFcr2007110_CR62) 2001; 292 S Mizumatsu (BFcr2007110_CR57) 2003; 63 Z Lou (BFcr2007110_CR16) 2006; 312 I Ferrer (BFcr2007110_CR53) 1992; 588 C Assuncao Guimaraes (BFcr2007110_CR38) 2004; 271 I Ferrer (BFcr2007110_CR54) 1993; 86 R Linden (BFcr2007110_CR73) 1996; 56 HL Borges (BFcr2007110_CR48) 2004; 11 MA Bewick (BFcr2007110_CR79) 2006; 12 M Blank (BFcr2007110_CR2) 2007; 6 MC Raff (BFcr2007110_CR51) 1992; 356 Z Wu (BFcr2007110_CR66) 2002; 22 Y Chen (BFcr2007110_CR18) 1998; 282 PM Domingos (BFcr2007110_CR20) 2007; 17 N Raver-Shapira (BFcr2007110_CR33) 2007; 26 X Lu (BFcr2007110_CR29) 2007; 12 J Rudolph (BFcr2007110_CR11) 2007; 7 R Linden (BFcr2007110_CR52) 1999; 18 SY Proskuryakov (BFcr2007110_CR42) 2003; 283 SC Short (BFcr2007110_CR15) 2005; 164 KC Yao (BFcr2007110_CR39) 2003; 98 AJ Watson (BFcr2007110_CR46) 1995; 109 A Craig (BFcr2007110_CR68) 2003; 4 WP Roos (BFcr2007110_CR3) 2006; 12 HL Borges (BFcr2007110_CR47) 2007; 26 JY Wang (BFcr2007110_CR6) 2004; 69 F Mollinedo (BFcr2007110_CR76) 2006; 9 S Mansilla (BFcr2007110_CR14) 2006; 6 JR Jeffers (BFcr2007110_CR59) 2003; 4 D Michod (BFcr2007110_CR5) 2007; 63 MS Bentle (BFcr2007110_CR4) 2006; 37 S Fujita (BFcr2007110_CR75) 1962; 28 C D'Sa (BFcr2007110_CR63) 2003; 74 C Chao (BFcr2007110_CR70) 2000; 97 H Takai (BFcr2007110_CR65) 2002; 21 MP Deyoung (BFcr2007110_CR28) 2007; 26 S Coppola (BFcr2007110_CR45) 1995; 221 JC Harrison (BFcr2007110_CR13) 2006; 40 JF Kerr (BFcr2007110_CR36) 2002; 181–182 N Festjens (BFcr2007110_CR43) 2006; 1757 KH Herzog (BFcr2007110_CR50) 1998; 280 P Jeggo (BFcr2007110_CR8) 2006; 122 T Truong (BFcr2007110_CR78) 2003; 100 WX Zong (BFcr2007110_CR44) 2004; 18 T Lindsten (BFcr2007110_CR61) 2000; 6 P Hahn (BFcr2007110_CR64) 2004; 11 L Yu (BFcr2007110_CR40) 2004; 304 B Schumacher (BFcr2007110_CR21) 2001; 11 HL Borges (BFcr2007110_CR55) 1999; 112 HK Lorenzo (BFcr2007110_CR35) 1999; 6 L Liu (BFcr2007110_CR69) 1999; 19 TA Ferguson (BFcr2007110_CR77) 2006; 213
References_xml	– volume: 213 start-page: 228 year: 2006 end-page: 238 ident: CR77 article-title: A vision of cell death: Fas ligand and immune privilege 10 years later publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2006.00430.x – volume: 312 start-page: 2641 year: 2006 end-page: 2646 ident: CR16 article-title: Cellular senescence and DNA repair publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2006.06.009 – volume: 112 start-page: 4315 issue: Pt 23 year: 1999 end-page: 4324 ident: CR55 article-title: Gamma irradiation leads to two waves of apoptosis in distinct cell populations of the retina of newborn rats publication-title: J Cell Sci – volume: 11 start-page: 4349 year: 1999 end-page: 4356 ident: CR74 article-title: Selective sensitivity of early postmitotic retinal cells to apoptosis induced by inhibition of protein synthesis publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.1999.00868.x – volume: 28 start-page: 52 year: 1962 end-page: 60 ident: CR75 article-title: Kinetics of cellular proliferation publication-title: Exp Cell Res doi: 10.1016/0014-4827(62)90311-7 – volume: 4 start-page: 321 year: 2003 end-page: 328 ident: CR59 article-title: Puma is an essential mediator of p53-dependent and -independent apoptotic pathways publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00244-7 – volume: 9 start-page: 691 year: 2004 end-page: 704 ident: CR26 article-title: Apoptosome dysfunction in human cancer publication-title: Apoptosis doi: 10.1023/B:APPT.0000045786.98031.1d – volume: 97 start-page: 889 year: 2000 end-page: 894 ident: CR60 article-title: Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.2.889 – volume: 19 start-page: 238 year: 2007 end-page: 245 ident: CR10 article-title: DNA damage checkpoints: from initiation to recovery or adaptation publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2007.02.009 – volume: 63 start-page: 4021 year: 2003 end-page: 4027 ident: CR57 article-title: Extreme sensitivity of adult neurogenesis to low doses of X-irradiation publication-title: Cancer Res – volume: 6 start-page: 516 year: 1999 end-page: 524 ident: CR35 article-title: Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4400527 – volume: 407 start-page: 777 year: 2000 end-page: 783 ident: CR1 article-title: Defying death after DNA damage publication-title: Nature doi: 10.1038/35037717 – volume: 7 start-page: 202 year: 2007 end-page: 211 ident: CR11 article-title: Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases publication-title: Nat Rev Cancer doi: 10.1038/nrc2087 – volume: 12 start-page: 440 year: 2006 end-page: 450 ident: CR3 article-title: DNA damage-induced cell death by apoptosis publication-title: Trends Mol Med doi: 10.1016/j.molmed.2006.07.007 – volume: 9 start-page: 51 year: 2006 end-page: 73 ident: CR76 article-title: Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy publication-title: Drug Resist Updat doi: 10.1016/j.drup.2006.04.002 – volume: 21 start-page: 6687 year: 2001 end-page: 6693 ident: CR72 article-title: Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-17-06687.2001 – volume: 221 start-page: 462 year: 1995 end-page: 469 ident: CR45 article-title: Different basal NAD levels determine opposite effects of poly(ADP-ribosyl)polymerase inhibitors on H2O2-induced apoptosis publication-title: Exp Cell Res doi: 10.1006/excr.1995.1397 – volume: 6 start-page: 686 year: 2007 end-page: 695 ident: CR2 article-title: Programs for cell death: apoptosis is only one way to go publication-title: Cell Cycle doi: 10.4161/cc.6.6.3990 – volume: 25 start-page: 2615 year: 2006 end-page: 2622 ident: CR49 article-title: Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression publication-title: Embo J – volume: 22 start-page: 2441 year: 2002 end-page: 2449 ident: CR66 article-title: Mutation of mouse p53 Ser23 and the response to DNA damage publication-title: Mol Cell Biol doi: 10.1128/MCB.22.8.2441-2449.2002 – volume: 12 start-page: 2833 year: 2006 end-page: 2848 ident: CR79 article-title: Adhesion dependent signalling in the tumour microenvironment: the future of drug targetting publication-title: Curr Pharm Des doi: 10.2174/138161206777947704 – volume: 19 start-page: 1202 year: 1999 end-page: 1209 ident: CR69 article-title: p53 sites acetylated by PCAF and p300 are acetylated in response to DNA damage publication-title: Mol Cell Biol doi: 10.1128/MCB.19.2.1202 – volume: 12 start-page: 153 year: 2005 end-page: 161 ident: CR22 article-title: ced-13 can promote apoptosis and is induced in response to DNA damage publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401539 – volume: 38 start-page: 652 year: 2007 end-page: 660 ident: CR41 article-title: Key note lecture: toward a mechanistic taxonomy for cell death programs publication-title: Stroke doi: 10.1161/01.STR.0000257802.82826.a7 – volume: 11 start-page: 1192 year: 2004 end-page: 1197 ident: CR64 article-title: Deficiency of Bax and Bak protects photoreceptors from light damage publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401486 – volume: 63 start-page: 160 year: 2007 end-page: 171 ident: CR5 article-title: DNA-damage sensitizers: potential new therapeutical tools to improve chemotherapy publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2007.04.003 – volume: 122 start-page: 124 year: 2006 end-page: 127 ident: CR8 article-title: Radiation-induced DNA damage responses publication-title: Radiat Prot Dosimetry doi: 10.1093/rpd/ncl495 – volume: 588 start-page: 351 year: 1992 end-page: 357 ident: CR53 article-title: The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex publication-title: Brain Res doi: 10.1016/0006-8993(92)91599-A – volume: 18 start-page: 115 year: 2007 end-page: 127, x ident: CR58 article-title: Radiation response of neural precursor cells publication-title: Neurosurg Clin N Am doi: 10.1016/j.nec.2006.10.010 – volume: 6 start-page: 931 year: 2007 end-page: 942 ident: CR9 article-title: ATM activation and DNA damage response publication-title: Cell Cycle doi: 10.4161/cc.6.8.4180 – volume: 36 start-page: 147 year: 2004 end-page: 150 ident: CR31 article-title: Dynamics of the p53-Mdm2 feedback loop in individual cells publication-title: Nat Genet doi: 10.1038/ng1293 – volume: 447 start-page: 1130 year: 2007 end-page: 1134 ident: CR32 article-title: A microRNA component of the p53 tumour suppressor network publication-title: Nature doi: 10.1038/nature05939 – volume: 6 start-page: 1389 year: 2000 end-page: 1399 ident: CR61 article-title: The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00136-2 – volume: 26 start-page: 6859 year: 2006 end-page: 6869 ident: CR71 article-title: Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage publication-title: Mol Cell Biol doi: 10.1128/MCB.00062-06 – volume: 14 start-page: 32 year: 2007 end-page: 43 ident: CR19 article-title: Caspase function in programmed cell death publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4402060 – volume: 26 start-page: 5169 year: 2007 end-page: 5183 ident: CR28 article-title: p63 and p73 in human cancer: defining the network publication-title: Oncogene doi: 10.1038/sj.onc.1210337 – volume: 56 start-page: 89 issue: Su 1 Pt 1 year: 1996 end-page: 103 ident: CR73 article-title: Death in a dish: controls of apoptosis within the developing retinal tissue publication-title: Rev Bras Biol – volume: 164 start-page: 292 year: 2005 end-page: 302 ident: CR15 article-title: DNA damage responses at low radiation doses publication-title: Radiat Res doi: 10.1667/RR3421.1 – volume: 280 start-page: 1089 year: 1998 end-page: 1091 ident: CR50 article-title: Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system publication-title: Science doi: 10.1126/science.280.5366.1089 – volume: 97 start-page: 11936 year: 2000 end-page: 11941 ident: CR70 article-title: Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.220252297 – volume: 6 start-page: 589 year: 2006 end-page: 602 ident: CR14 article-title: Mitotic catastrophe as a consequence of chemotherapy publication-title: Anticancer Agents Med Chem doi: 10.2174/187152006778699086 – volume: 115 start-page: 4727 year: 2002 end-page: 4734 ident: CR34 article-title: Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? publication-title: J Cell Sci doi: 10.1242/jcs.00210 – volume: 98 start-page: 378 year: 2003 end-page: 384 ident: CR39 article-title: Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy publication-title: J Neurosurg doi: 10.3171/jns.2003.98.2.0378 – volume: 282 start-page: 691 year: 1998 end-page: 702 ident: CR18 article-title: Shaping limbs by apoptosis publication-title: J Exp Zool doi: 10.1002/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S – volume: 37 start-page: 961 year: 2005 end-page: 976 ident: CR7 article-title: The signals and pathways activating cellular senescence publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2004.10.013 – volume: 14 start-page: 595 year: 2005 end-page: 599 ident: CR37 article-title: Caspase-dependent and -independent cell death pathways after DNA damage (Review) publication-title: Oncol Rep – volume: 18 start-page: 1272 year: 2004 end-page: 1282 ident: CR44 article-title: Alkylating DNA damage stimulates a regulated form of necrotic cell death publication-title: Genes Dev doi: 10.1101/gad.1199904 – volume: 11 start-page: 1722 year: 2001 end-page: 1727 ident: CR21 article-title: The homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis publication-title: Curr Biol doi: 10.1016/S0960-9822(01)00534-6 – volume: 304 start-page: 1500 year: 2004 end-page: 1502 ident: CR40 article-title: Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 publication-title: Science doi: 10.1126/science.1096645 – volume: 18 start-page: 133 year: 1999 end-page: 165 ident: CR52 article-title: Apoptosis in developing retinal tissue publication-title: Prog Retin Eye Res doi: 10.1016/S1350-9462(98)00020-2 – volume: 86 start-page: 491 year: 1993 end-page: 500 ident: CR54 article-title: Radiosensitive populations and recovery in X-ray-induced apoptosis in the developing cerebellum publication-title: Acta Neuropathol – volume: 14 start-page: 289 year: 2000 end-page: 300 ident: CR67 article-title: The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites publication-title: Genes Dev – volume: 11 start-page: 494 year: 2004 end-page: 502 ident: CR48 article-title: Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401366 – volume: 12 start-page: 342 year: 2007 end-page: 354 ident: CR29 article-title: The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.08.033 – volume: 13 start-page: 2129 year: 2006 end-page: 2139 ident: CR23 article-title: Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401976 – volume: 74 start-page: 435 year: 2003 end-page: 445 ident: CR63 article-title: Caspase regulation of genotoxin-induced neural precursor cell death publication-title: J Neurosci Res doi: 10.1002/jnr.10738 – volume: 40 start-page: 209 year: 2006 end-page: 235 ident: CR13 article-title: Surviving the breakup: the DNA damage checkpoint publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.40.051206.105231 – volume: 130 start-page: 597 year: 2007 end-page: 600 ident: CR30 article-title: Living with p53, dying of p53 publication-title: Cell doi: 10.1016/j.cell.2007.08.005 – volume: 1757 start-page: 1371 year: 2006 end-page: 1387 ident: CR43 article-title: Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response publication-title: Biochim Biophys Acta doi: 10.1016/j.bbabio.2006.06.014 – volume: 17 start-page: 294 year: 2007 end-page: 299 ident: CR20 article-title: Pathways regulating apoptosis during patterning and development publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2007.05.009 – volume: 6 start-page: 414 year: 2007 end-page: 417 ident: CR17 article-title: ATM and ATR: components of an integrated circuit publication-title: Cell Cycle doi: 10.4161/cc.6.4.3886 – volume: 271 start-page: 1638 year: 2004 end-page: 1650 ident: CR38 article-title: Programmed cell deaths. Apoptosis and alternative deathstyles publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.2004.04084.x – volume: 4 start-page: 313 year: 2001 end-page: 332 ident: CR25 article-title: Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene publication-title: J Toxicol Environ Health B Crit Rev doi: 10.1080/109374001301419737 – volume: 416 start-page: 560 year: 2002 end-page: 564 ident: CR27 article-title: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage publication-title: Nature doi: 10.1038/416560a – volume: 100 start-page: 10281 year: 2003 end-page: 10286 ident: CR78 article-title: Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1635435100 – volume: 356 start-page: 397 year: 1992 end-page: 400 ident: CR51 article-title: Social controls on cell survival and cell death publication-title: Nature doi: 10.1038/356397a0 – volume: 283 start-page: 1 year: 2003 end-page: 16 ident: CR42 article-title: Necrosis: a specific form of programmed cell death? publication-title: Exp Cell Res doi: 10.1016/S0014-4827(02)00027-7 – volume: 145 start-page: 1365 year: 2007 end-page: 1374 ident: CR56 article-title: Responding to DNA double strand breaks in the nervous system publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.07.026 – volume: 4 start-page: 787 year: 2003 end-page: 792 ident: CR68 article-title: Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain publication-title: EMBO Rep doi: 10.1038/sj.embor.embor901 – volume: 7 start-page: 495 year: 2007 end-page: 507 ident: CR12 article-title: CDC25 phosphatases in cancer cells: key players? Good targets? publication-title: Nat Rev Cancer doi: 10.1038/nrc2169 – volume: 292 start-page: 727 year: 2001 end-page: 730 ident: CR62 article-title: Proapoptotic BAX, BAK: a requisite gateway to mitochondrial dysfunction and death publication-title: Science doi: 10.1126/science.1059108 – volume: 69 start-page: 101 year: 2004 end-page: 135 ident: CR6 article-title: Coordination of repair, checkpoint, and cell death responses to DNA damage publication-title: Adv Protein Chem doi: 10.1016/S0065-3233(04)69004-8 – volume: 4 start-page: 248 year: 2003 end-page: 249 ident: CR24 article-title: No PUMA, no death: implications for p53-dependent apoptosis publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00249-6 – volume: 181–182 start-page: 471 year: 2002 end-page: 474 ident: CR36 article-title: History of the events leading to the formulation of the apoptosis concept publication-title: Toxicology doi: 10.1016/S0300-483X(02)00457-2 – volume: 109 start-page: 472 year: 1995 end-page: 482 ident: CR46 article-title: Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis publication-title: Gastroenterology doi: 10.1016/0016-5085(95)90335-6 – volume: 21 start-page: 5195 year: 2002 end-page: 5205 ident: CR65 article-title: Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription publication-title: Embo J doi: 10.1093/emboj/cdf506 – volume: 37 start-page: 203 year: 2006 end-page: 218 ident: CR4 article-title: New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors publication-title: J Mol Histol doi: 10.1007/s10735-006-9043-8 – volume: 26 start-page: 731 year: 2007 end-page: 743 ident: CR33 article-title: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis publication-title: Mol Cell doi: 10.1016/j.molcel.2007.05.017 – volume: 26 start-page: 3868 year: 2007 end-page: 3877 ident: CR47 article-title: Reduction of apoptosis in Rb-deficient embryos via Abl knockout publication-title: Oncogene doi: 10.1038/sj.onc.1210157 – volume: 122 start-page: 124 year: 2006 ident: BFcr2007110_CR8 publication-title: Radiat Prot Dosimetry doi: 10.1093/rpd/ncl495 – volume: 74 start-page: 435 year: 2003 ident: BFcr2007110_CR63 publication-title: J Neurosci Res doi: 10.1002/jnr.10738 – volume: 12 start-page: 153 year: 2005 ident: BFcr2007110_CR22 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401539 – volume: 7 start-page: 495 year: 2007 ident: BFcr2007110_CR12 publication-title: Nat Rev Cancer doi: 10.1038/nrc2169 – volume: 130 start-page: 597 year: 2007 ident: BFcr2007110_CR30 publication-title: Cell doi: 10.1016/j.cell.2007.08.005 – volume: 18 start-page: 115 year: 2007 ident: BFcr2007110_CR58 publication-title: Neurosurg Clin N Am doi: 10.1016/j.nec.2006.10.010 – volume: 13 start-page: 2129 year: 2006 ident: BFcr2007110_CR23 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401976 – volume: 14 start-page: 595 year: 2005 ident: BFcr2007110_CR37 publication-title: Oncol Rep – volume: 109 start-page: 472 year: 1995 ident: BFcr2007110_CR46 publication-title: Gastroenterology doi: 10.1016/0016-5085(95)90335-6 – volume: 63 start-page: 4021 year: 2003 ident: BFcr2007110_CR57 publication-title: Cancer Res – volume: 26 start-page: 6859 year: 2006 ident: BFcr2007110_CR71 publication-title: Mol Cell Biol doi: 10.1128/MCB.00062-06 – volume: 9 start-page: 51 year: 2006 ident: BFcr2007110_CR76 publication-title: Drug Resist Updat doi: 10.1016/j.drup.2006.04.002 – volume: 213 start-page: 228 year: 2006 ident: BFcr2007110_CR77 publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2006.00430.x – volume: 6 start-page: 686 year: 2007 ident: BFcr2007110_CR2 publication-title: Cell Cycle doi: 10.4161/cc.6.6.3990 – volume: 38 start-page: 652 year: 2007 ident: BFcr2007110_CR41 publication-title: Stroke doi: 10.1161/01.STR.0000257802.82826.a7 – volume: 6 start-page: 1389 year: 2000 ident: BFcr2007110_CR61 publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00136-2 – volume: 280 start-page: 1089 year: 1998 ident: BFcr2007110_CR50 publication-title: Science doi: 10.1126/science.280.5366.1089 – volume: 282 start-page: 691 year: 1998 ident: BFcr2007110_CR18 publication-title: J Exp Zool doi: 10.1002/(SICI)1097-010X(19981215)282:6<691::AID-JEZ5>3.0.CO;2-S – volume: 26 start-page: 731 year: 2007 ident: BFcr2007110_CR33 publication-title: Mol Cell doi: 10.1016/j.molcel.2007.05.017 – volume: 4 start-page: 248 year: 2003 ident: BFcr2007110_CR24 publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00249-6 – volume: 12 start-page: 2833 year: 2006 ident: BFcr2007110_CR79 publication-title: Curr Pharm Des doi: 10.2174/138161206777947704 – volume: 28 start-page: 52 year: 1962 ident: BFcr2007110_CR75 publication-title: Exp Cell Res doi: 10.1016/0014-4827(62)90311-7 – volume: 40 start-page: 209 year: 2006 ident: BFcr2007110_CR13 publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.40.051206.105231 – volume: 356 start-page: 397 year: 1992 ident: BFcr2007110_CR51 publication-title: Nature doi: 10.1038/356397a0 – volume: 4 start-page: 321 year: 2003 ident: BFcr2007110_CR59 publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00244-7 – volume: 283 start-page: 1 year: 2003 ident: BFcr2007110_CR42 publication-title: Exp Cell Res doi: 10.1016/S0014-4827(02)00027-7 – volume: 26 start-page: 5169 year: 2007 ident: BFcr2007110_CR28 publication-title: Oncogene doi: 10.1038/sj.onc.1210337 – volume: 17 start-page: 294 year: 2007 ident: BFcr2007110_CR20 publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2007.05.009 – volume: 14 start-page: 289 year: 2000 ident: BFcr2007110_CR67 publication-title: Genes Dev doi: 10.1101/gad.14.3.289 – volume: 69 start-page: 101 year: 2004 ident: BFcr2007110_CR6 publication-title: Adv Protein Chem doi: 10.1016/S0065-3233(04)69004-8 – volume: 11 start-page: 1722 year: 2001 ident: BFcr2007110_CR21 publication-title: Curr Biol doi: 10.1016/S0960-9822(01)00534-6 – volume: 164 start-page: 292 year: 2005 ident: BFcr2007110_CR15 publication-title: Radiat Res doi: 10.1667/RR3421.1 – volume: 6 start-page: 414 year: 2007 ident: BFcr2007110_CR17 publication-title: Cell Cycle doi: 10.4161/cc.6.4.3886 – volume: 115 start-page: 4727 year: 2002 ident: BFcr2007110_CR34 publication-title: J Cell Sci doi: 10.1242/jcs.00210 – volume: 56 start-page: 89 issue: Su 1 Pt 1 year: 1996 ident: BFcr2007110_CR73 publication-title: Rev Bras Biol – volume: 14 start-page: 32 year: 2007 ident: BFcr2007110_CR19 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4402060 – volume: 181–182 start-page: 471 year: 2002 ident: BFcr2007110_CR36 publication-title: Toxicology doi: 10.1016/S0300-483X(02)00457-2 – volume: 9 start-page: 691 year: 2004 ident: BFcr2007110_CR26 publication-title: Apoptosis doi: 10.1023/B:APPT.0000045786.98031.1d – volume: 21 start-page: 5195 year: 2002 ident: BFcr2007110_CR65 publication-title: Embo J doi: 10.1093/emboj/cdf506 – volume: 6 start-page: 589 year: 2006 ident: BFcr2007110_CR14 publication-title: Anticancer Agents Med Chem doi: 10.2174/187152006778699086 – volume: 12 start-page: 342 year: 2007 ident: BFcr2007110_CR29 publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.08.033 – volume: 36 start-page: 147 year: 2004 ident: BFcr2007110_CR31 publication-title: Nat Genet doi: 10.1038/ng1293 – volume: 63 start-page: 160 year: 2007 ident: BFcr2007110_CR5 publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2007.04.003 – volume: 271 start-page: 1638 year: 2004 ident: BFcr2007110_CR38 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.2004.04084.x – volume: 7 start-page: 202 year: 2007 ident: BFcr2007110_CR11 publication-title: Nat Rev Cancer doi: 10.1038/nrc2087 – volume: 292 start-page: 727 year: 2001 ident: BFcr2007110_CR62 publication-title: Science doi: 10.1126/science.1059108 – volume: 4 start-page: 313 year: 2001 ident: BFcr2007110_CR25 publication-title: J Toxicol Environ Health B Crit Rev doi: 10.1080/109374001301419737 – volume: 145 start-page: 1365 year: 2007 ident: BFcr2007110_CR56 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.07.026 – volume: 407 start-page: 777 year: 2000 ident: BFcr2007110_CR1 publication-title: Nature doi: 10.1038/35037717 – volume: 97 start-page: 889 year: 2000 ident: BFcr2007110_CR60 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.2.889 – volume: 588 start-page: 351 year: 1992 ident: BFcr2007110_CR53 publication-title: Brain Res doi: 10.1016/0006-8993(92)91599-A – volume: 447 start-page: 1130 year: 2007 ident: BFcr2007110_CR32 publication-title: Nature doi: 10.1038/nature05939 – volume: 22 start-page: 2441 year: 2002 ident: BFcr2007110_CR66 publication-title: Mol Cell Biol doi: 10.1128/MCB.22.8.2441-2449.2002 – volume: 12 start-page: 440 year: 2006 ident: BFcr2007110_CR3 publication-title: Trends Mol Med doi: 10.1016/j.molmed.2006.07.007 – volume: 21 start-page: 6687 year: 2001 ident: BFcr2007110_CR72 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-17-06687.2001 – volume: 6 start-page: 516 year: 1999 ident: BFcr2007110_CR35 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4400527 – volume: 97 start-page: 11936 year: 2000 ident: BFcr2007110_CR70 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.220252297 – volume: 11 start-page: 4349 year: 1999 ident: BFcr2007110_CR74 publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.1999.00868.x – volume: 4 start-page: 787 year: 2003 ident: BFcr2007110_CR68 publication-title: EMBO Rep doi: 10.1038/sj.embor.embor901 – volume: 112 start-page: 4315 issue: Pt 23 year: 1999 ident: BFcr2007110_CR55 publication-title: J Cell Sci doi: 10.1242/jcs.112.23.4315 – volume: 6 start-page: 931 year: 2007 ident: BFcr2007110_CR9 publication-title: Cell Cycle doi: 10.4161/cc.6.8.4180 – volume: 416 start-page: 560 year: 2002 ident: BFcr2007110_CR27 publication-title: Nature doi: 10.1038/416560a – volume: 98 start-page: 378 year: 2003 ident: BFcr2007110_CR39 publication-title: J Neurosurg doi: 10.3171/jns.2003.98.2.0378 – volume: 26 start-page: 3868 year: 2007 ident: BFcr2007110_CR47 publication-title: Oncogene doi: 10.1038/sj.onc.1210157 – volume: 18 start-page: 1272 year: 2004 ident: BFcr2007110_CR44 publication-title: Genes Dev doi: 10.1101/gad.1199904 – volume: 25 start-page: 2615 year: 2006 ident: BFcr2007110_CR49 publication-title: Embo J – volume: 86 start-page: 491 year: 1993 ident: BFcr2007110_CR54 publication-title: Acta Neuropathol – volume: 100 start-page: 10281 year: 2003 ident: BFcr2007110_CR78 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1635435100 – volume: 37 start-page: 961 year: 2005 ident: BFcr2007110_CR7 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2004.10.013 – volume: 37 start-page: 203 year: 2006 ident: BFcr2007110_CR4 publication-title: J Mol Histol doi: 10.1007/s10735-006-9043-8 – volume: 304 start-page: 1500 year: 2004 ident: BFcr2007110_CR40 publication-title: Science doi: 10.1126/science.1096645 – volume: 11 start-page: 494 year: 2004 ident: BFcr2007110_CR48 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401366 – volume: 18 start-page: 133 year: 1999 ident: BFcr2007110_CR52 publication-title: Prog Retin Eye Res doi: 10.1016/S1350-9462(98)00020-2 – volume: 221 start-page: 462 year: 1995 ident: BFcr2007110_CR45 publication-title: Exp Cell Res doi: 10.1006/excr.1995.1397 – volume: 312 start-page: 2641 year: 2006 ident: BFcr2007110_CR16 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2006.06.009 – volume: 19 start-page: 238 year: 2007 ident: BFcr2007110_CR10 publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2007.02.009 – volume: 1757 start-page: 1371 year: 2006 ident: BFcr2007110_CR43 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbabio.2006.06.014 – volume: 11 start-page: 1192 year: 2004 ident: BFcr2007110_CR64 publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401486 – volume: 19 start-page: 1202 year: 1999 ident: BFcr2007110_CR69 publication-title: Mol Cell Biol doi: 10.1128/MCB.19.2.1202
SSID	ssj0025451
Score	2.2766578
SecondaryResourceType	review_article
Snippet	DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death... DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and - independent death...
SourceID	pubmedcentral proquest pubmed crossref springer chongqing
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	17
SubjectTerms	Animals Apoptosis - genetics Apoptosis - radiation effects Biomedical and Life Sciences Caspases - metabolism Caspases - physiology Cell Biology Cell death Cell Death - genetics Cell Death - radiation effects Central nervous system Deoxyribonucleic acid DNA DNA Damage - physiology DNA Fragmentation Enzyme Activation - physiology Enzyme Activation - radiation effects Humans Ionizing radiation Life Sciences Models, Biological Mortality Radiation Dosage Radiation Injuries, Experimental - genetics Radiation, Ionizing Retina - growth & development Retina - radiation effects review 死亡过程神经系统脱氧核糖核酸
Title	DNA damage-induced cell death： lessons from the central nervous system
URI	http://lib.cqvip.com/qk/85240X/20081/26520101.html https://link.springer.com/article/10.1038/cr.2007.110 https://www.ncbi.nlm.nih.gov/pubmed/18087290 https://www.proquest.com/docview/1027546803 https://www.proquest.com/docview/20640003 https://www.proquest.com/docview/70187587 https://pubmed.ncbi.nlm.nih.gov/PMC2626635
Volume	18
WOSCitedRecordID	wos000252920000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1748-7838 dateEnd: 20181231 omitProxy: false ssIdentifier: ssj0025451 issn: 1001-0602 databaseCode: M7P dateStart: 20000301 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1748-7838 dateEnd: 20181231 omitProxy: false ssIdentifier: ssj0025451 issn: 1001-0602 databaseCode: 7X7 dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1748-7838 dateEnd: 20181231 omitProxy: false ssIdentifier: ssj0025451 issn: 1001-0602 databaseCode: BENPR dateStart: 20000301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9tAEB6Vl9pLy6O0LpDuAS5IFo7t9a57qWhLxKGKIgRSbpZ3vG5RwYEkVOq_78zaMQ0pXLjEB6-cfczMzrcz-w3AfoKEbrql8REJ6cSlSn1NjjEpHtoy5LufpSNx_a76fT0cpoPmwG3SpFXObKIz1MUI-YyctDtUMk50EH2-ufW5ahRHV5sSGkuwwiwJoUvdG7SAi7wDB7hc2lDCmTyb9TVzfYTjmr6wy1dnX5KlqX7c0l4xvzstuJyLmZMPwqduV-q9ee541uF144-K41qANuCFrTZhra5Q-WcLet_6x6LIr8nq-ITeSQ4KwWf9omDX8ZO4IkNJciv4loogX1I0XRYV2aDR3UTUTNFv4aJ3cv711G9KL_gog3Dqo84TbQ3GCjnQmhMss_wIbGoITidFhEGMgUHCc7qUGIVptzBFiqWVCqWNtmG5GlX2PQiJMkZTBDo1Jg5NTF9OUFlpS4055qkHO-3009aNv5iQKgsTyXH6rgeHswXJsGEt5-IZV5mLnkc6wzGX0lQEZQIP9tvGNzVZx_-b7c6WJGs0dpLdr4cHH9vXpGs8qXllacroA0nMIPLxFoprHEqtPHhXC8p9P3SgCcjQn6s5EWobMM_3_Jvq8qfj-w4JdJJf6MHBTNj-7fbC8D48PbwdeFXnvPAx0i4sT8d3dg9W8ff0cjLuwJIaKverO7Dy5aQ_OOs4pfoL3Wkm7Q
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAmovPMqjaQv1ob0gRWSdOHYqIVRRVq26rDgUaW8hGTuwomTb3S2of4rfyEweuywL3HrglIMtxx7PjOez5wGwFyOhm06R-4iEdKJCJ74hw5gED10hOfazqJK49nS_bwaD5P0K_GhjYditstWJlaK2I-Q7cpJuqVUUmyB8fXHpc9Uofl1tS2jUbHHqrr8TZJu8Ojmi_d2Xsvv27M2x31QV8FEFcuqjyWLjcow08htiRojD8SdwSU5IMbYhBhEGORJUMYXCUCYdm9sEC6c0KhfSuLfgNulxzWBPD-YAj6yRCuBVbkoxew5t1GHt5iWO63SJHQ7VXSPNVn66pLNp8TRcMnGXPTV_e66tTsHu_f-Nfg_gXmNvi8NaQB7Ciis34G5dgfP6EXSP-ofCZl9Jq_rD0hKfW8FvGcKyaXwgzukgILkUHIUjyFYWDYlESTp2dDURdSbsx_DhRhbxBFbLUek2QShUEeY2MEmeRzKPaOQYtVOuMJhhlniwPdtuMk3wCyfcSmWs2A-h48GLlgFSbLKyc3GQ87TyDghNimMuFaoJqgUe7M06X9TJSP7cbadlgbTRSJN0vv8e7M6aSZcwUbPSEclogDhikPz3HpprOCqjPXhaM-Z8HiYwBNTo53qBZWcdOI_5Yks5_FzlM5cEqsnu9WC_Ze5fp720vK1_L28X1o7P3vXS3kn_dBvWa_8evjLbgdXp-Mo9gzv4bTqcjJ9Xwivg401z-08wm4EM
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLa8Lj_IKLdSH9oIUNZvYsYOEUGG7omoVrRBIvaXJxIEVJdvubkH9a_w6ZvIqywK3HjjlYMuxnZnx98XzANgKkdhNv8hcRGI6stCRawgYk-KhLXyO_SyqJK6HOo7N0VE0WoEfbSwMu1W2NrEy1PkE-R85abevlQyNF-wUjVvEaDB8fXrmcgUpvmlty2nUInJgL74TfZu92h_Qt972_eHeh7fv3KbCgIvK8-cumjQ0NkOpke8TU2Iflh-ejTJijWEeoCfRy5BoiykUBn7Uz7M8wsIqjcoGNO41WNUEMmQPVt_sxaP3Hd0jbFLRvcppKWQ_orU6yN3s4LROntjnwN1bZOfKT2d0Ui2ejUuAd9lv87fL2-pMHN79n3fzHtxpkLjYrVXnPqzYcg1u1LU5Lx7AcBDvijz9SvbWHZc5aUAu-JZD5AyaX4oTOiJIYwXH5whC0aLZLlGS9Z2cz0SdI_shfLySRTyCXjkp7RMQCpXELPdMlGXSzySNHKK2yhYGU0wjB9a7T0-gBb9wKq7EDxV7KPQdeNEKQ4JNvnYuG3KSVH4DgUlwykVENZE4z4GtrvNpnabkz902WnFIGls1Sy5lwYHNrpmsDG9qWlraMhoglEyf_95Dc3VHZbQDj2shvZyH8QxROHq5XhDfrgNnOF9sKcefq0znPtFtQsQObLeC_uu0l5b39N_L24SbJOTJ4X58sA63a8cf_pe2Ab359Nw-g-v4bT6eTZ83mizg-KrF_Sdk74ss
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DNA+damage-induced+cell+death%3A+lessons+from+the+central+nervous+system&rft.jtitle=Cell+research&rft.au=Borges%2C+Helena+Lobo&rft.au=Linden%2C+Rafael&rft.au=Wang%2C+Jean+YJ&rft.date=2008-01-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=1001-0602&rft.eissn=1748-7838&rft.volume=18&rft.issue=1&rft.spage=17&rft.epage=26&rft_id=info:doi/10.1038%2Fcr.2007.110&rft.externalDocID=10_1038_cr_2007_110
thumbnail_s	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F85240X%2F85240X.jpg