Dengue Virus Infection and Associated Risk Factors in Africa: A Systematic Review and Meta-Analysis

Dengue contributes a significant burden on global public health and economies. In Africa, the burden of dengue virus (DENV) infection is not well described. This review was undertaken to determine the prevalence of dengue and associated risk factors. A literature search was done on PubMed/MEDLINE, S...

Full description

Saved in:
Bibliographic Details
Published in:Viruses Vol. 13; no. 4; p. 536
Main Authors: Mwanyika, Gaspary O., Mboera, Leonard E. G., Rugarabamu, Sima, Ngingo, Baraka, Sindato, Calvin, Lutwama, Julius J., Paweska, Janusz T., Misinzo, Gerald
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 24.03.2021
MDPI
Subjects:
Africa
Africa - epidemiology
Age Factors
Bias
Climate change
confidence interval
Cost of Illness
dengue
Dengue - epidemiology
Dengue fever
Dengue virus
Dengue Virus - classification
Disease Outbreaks - statistics & numerical data
disease severity
Epidemics
health policy
Humans
Infections
Laboratories
Meta-analysis
Morbidity
mosquito control
Mosquito Control - standards
Outbreaks
Prevalence
Public health
Review
Risk Factors
Sensitivity analysis
Serogroup
Serotypes
Severe Dengue - epidemiology
Severe Dengue - etiology
Software
Systematic review
travel
Tropical diseases
Urban Population
Viruses
Western Africa
Africa
Djibouti
Burkina Faso
Senegal
Sudan
Tanzania
Western Africa
prevalence
risk factors
dengue
Africa
ISSN:1999-4915, 1999-4915
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dengue contributes a significant burden on global public health and economies. In Africa, the burden of dengue virus (DENV) infection is not well described. This review was undertaken to determine the prevalence of dengue and associated risk factors. A literature search was done on PubMed/MEDLINE, Scopus, Embase, and Google Scholar databases to identify articles published between 1960 and 2020. Meta-analysis was performed using a random-effect model at a 95% confidence interval, followed by subgroup meta-analysis to determine the overall prevalence. Between 1960 and 2020, 45 outbreaks were identified, of which 17 and 16 occurred in East and West Africa, respectively. Dengue virus serotype 1 (DENV-1) and DENV-2 were the dominant serotypes contributing to 60% of the epidemics. Of 2211 cases reported between 2009 and 2020; 1954 (88.4%) were reported during outbreaks. Overall, the prevalence of dengue was 29% (95% CI: 20–39%) and 3% (95% CI: 1–5%) during the outbreak and non-outbreak periods, respectively. Old age (6/21 studies), lack of mosquito control (6/21), urban residence (4/21), climate change (3/21), and recent history of travel (3/21) were the leading risk factors. This review reports a high burden of dengue and increased risk of severe disease in Africa. Our findings provide useful information for clinical practice and health policy decisions to implement effective interventions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1999-4915
1999-4915
DOI:10.3390/v13040536