Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney....

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 52; no. 2; p. 374
Main Authors:	Li, Xiaoxue, Rommelaere, Samuel, Kondo, Shu, Lemaitre, Bruno
Format:	Journal Article
Language:	English
Published:	United States 18.02.2020
Subjects:	Adaptive Immunity Animals Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Diglycerides - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - immunology Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Feces - chemistry Hemolymph - metabolism Lipid Metabolism - immunology Lipid Peroxidation - immunology Malpighian Tubules - immunology Malpighian Tubules - metabolism MAP Kinase Signaling System - immunology Protein Conformation Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Stress, Physiological - immunology homeostasis stress excretion immune adaptation Drosophila ROS immunity lipid peroxidation Malpighian tubules
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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