Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney....

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Vydáno v:	Immunity (Cambridge, Mass.) Ročník 52; číslo 2; s. 374
Hlavní autoři:	Li, Xiaoxue, Rommelaere, Samuel, Kondo, Shu, Lemaitre, Bruno
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.02.2020
Témata:	Adaptive Immunity Animals Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Diglycerides - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - immunology Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Feces - chemistry Hemolymph - metabolism Lipid Metabolism - immunology Lipid Peroxidation - immunology Malpighian Tubules - immunology Malpighian Tubules - metabolism MAP Kinase Signaling System - immunology Protein Conformation Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Stress, Physiological - immunology homeostasis stress excretion immune adaptation Drosophila ROS immunity lipid peroxidation Malpighian tubules
ISSN:	1097-4180, 1097-4180
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Shrnutí:	Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney. This lipid purge was mediated by a stress-induced lipid-binding protein, Materazzi, which was enriched in Malpighian tubules. Flies lacking materazzi had higher hemolymph concentrations of reactive oxygen species (ROS) and increased lipid peroxidation. These flies also displayed Malpighian tubule dysfunction and were susceptible to infections and environmental stress. Feeding flies with antioxidants rescued the materazzi phenotype, indicating that the main role of Materazzi is to protect the organism from damage caused by stress-induced ROS. Our findings suggest that purging hemolymphatic lipids presents a physiological adaptation to protect host tissues from excessive ROS during immune and stress responses, a process that is likely to apply to other organisms.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4180 1097-4180
DOI:	10.1016/j.immuni.2020.01.008