Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work...

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Bibliographic Details
Published in:	Current opinion in neurobiology Vol. 15; no. 3; pp. 370 - 378
Main Authors:	Suh, Byung-Chang, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2005
Subjects:	Cell Membrane - chemistry Cell Membrane - physiology Ion Channels - physiology Phosphatidylinositol 4,5-Diphosphate - chemistry Phosphatidylinositol 4,5-Diphosphate - metabolism
ISSN:	0959-4388, 1873-6882
Online Access:	Get full text
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Summary:	Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2005.05.005